Application | Comment | Organism |
---|---|---|
pharmacology | peptide inhibitors reproducing the structure of the autoregulatory motif as possibility to develop effective antivirals | Hepacivirus C |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Hepacivirus C |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | inhibitory potential of sequences of NTPase/helicase motifs VI derived peptides and their deleted derivatives analyzed, NTP-binding and hydrolyzing site not involved | Hepacivirus C |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Hepacivirus C | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O | Hepacivirus C | - |
ADP + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Hepacivirus C | - |
- |
- |
Purification (Comment) | Organism |
---|---|
gel filtration, SDS-PAGE | Hepacivirus C |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
overview of sequences of NTPase/helicase motifs VI derived peptides and their deleted derivatives, kinetic analyses reveals that binding of the peptides do not interfere with the NTPase activity, peptides do not interact with the ATP binding site | Hepacivirus C |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O | - |
Hepacivirus C | ADP + phosphate | - |
? | |
ATP + H2O | peptide inhibitors derived from amino acid sequence of motif VI analyzed, binding of the inhibitory peptides does not interfere with the NTPase activity | Hepacivirus C | ADP + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
non structural protein 3 | ambiguous | Hepacivirus C |
NTPase/helicase | ambiguous | Hepacivirus C |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
additional information | - |
sequences of NTPase/helicase motifs VI derived peptides and their deleted derivatives analyzed, NTPase activity not affected | Hepacivirus C | additional information |