Activating Compound | Comment | Organism | Structure |
---|---|---|---|
DnaJ | - |
Bos taurus | |
DnaJ | interaction with DnaJ stimulates the hydrolysis of ATP by DnaK | Escherichia coli | |
GrpE | - |
Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.31 | - |
ADP | - |
Bos taurus | |
4.3 | - |
ATP | - |
Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Bos taurus | 5737 | - |
cytosol | - |
Bos taurus | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | Hsp70 activity stimulated by | Bos taurus | |
Mn2+ | Hsp70 activity stimulated by | Bos taurus | |
Ni2+ | Hsp70 activity stimulated by | Bos taurus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
70000 | - |
- |
Escherichia coli |
70000 | - |
- |
Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP + ATP | Escherichia coli | - |
ATP + ADP | - |
r | |
ADP + ATP | Bos taurus | - |
ATP + ADP | - |
r | |
ATP + H2O | Escherichia coli | - |
ADP + phosphate | - |
r | |
ATP + H2O | Bos taurus | - |
ADP + phosphate | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Escherichia coli | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Bos taurus |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + H2O = ADP + phosphate | highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin | Escherichia coli | |
ATP + H2O = ADP + phosphate | highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin | Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP + ATP | - |
Escherichia coli | ATP + ADP | - |
r | |
ADP + ATP | - |
Bos taurus | ATP + ADP | - |
r | |
ATP + H2O | - |
Escherichia coli | ADP + phosphate | - |
r | |
ATP + H2O | - |
Bos taurus | ADP + phosphate | - |
r | |
CDP + H2O | Hsp70 | Bos taurus | ? | - |
? | |
dCDP + H2O | Hsp70 | Bos taurus | ? | - |
? | |
dGDP + H2O | Hsp70 | Bos taurus | ? | - |
? | |
dTDP + H2O | Hsp70 | Bos taurus | ? | - |
? | |
GDP + H2O | Hsp70 | Bos taurus | ? | - |
? | |
UDP + H2O | Hsp70 | Bos taurus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Hsc70 | - |
Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
without ADP | Bos taurus |
7.5 | 9 | stimulated ATPase in presence of 0.5 mM ADP | Bos taurus |
7.5 | 8.5 | - |
Bos taurus |