Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli mutT2 mutant cells devoid of their own 8-oxo-dGTPase activity | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
17896 | - |
x * 17896, calculated from sequence | Mus musculus |
18000 | - |
x * 18000, SDS-PAGE | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
8-oxo-dGTP + H2O | Mus musculus | 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate (8-oxo-dGTP) is formed in the nucleotide pool of a cell during normal cellular metabolism, and when it is incorporated into DNA causes mutation. Organisms possess 8-oxo-dGTPase, an enzyme that specifically degrades 8-oxo-dGTP to 8-oxo-dGMP. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP | 8-oxo-dGMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P53368 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryonic stem cell | high level of activity | Mus musculus | - |
large intestine | high level of activity | Mus musculus | - |
liver | high level of activity | Mus musculus | - |
thymus | high level of activity | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
8-oxo-dGTP + H2O | 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate (8-oxo-dGTP) is formed in the nucleotide pool of a cell during normal cellular metabolism, and when it is incorporated into DNA causes mutation. Organisms possess 8-oxo-dGTPase, an enzyme that specifically degrades 8-oxo-dGTP to 8-oxo-dGMP. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP | Mus musculus | 8-oxo-dGMP + diphosphate | - |
? | |
8-oxo-dGTP + H2O | 8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP | Mus musculus | 8-oxo-dGMP + diphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 18000, SDS-PAGE | Mus musculus |
? | x * 17896, calculated from sequence | Mus musculus |