Protein Variants | Comment | Organism |
---|---|---|
E66Q | no significant activity towards diphosphoinositol pentakisphosphate or bisdiphosphoinositol tetrakisphosphate, activity with diadenosine 5',5'''-P1,P6-hexaphosphate is 2% of the activity of the wild-type enzyme | Homo sapiens |
E70Q | inactive against dATP,diphosphoinositol pentakisphosphate or bisdiphosphoinositol tetrakisphosphate | Homo sapiens |
F84Y | hydrolysis of bisdiphosphoinositol tetrakisphosphate at 63% of the activity of the wild-type enzyme, hydrolysis of diadenosine 5',5'''-P1,P6-hexaphosphate is 75% of the activity of the wild-type enzyme, activity with diphosphoinositol pentakisphosphate is only slightly reduced | Homo sapiens |
G50A | hydrolysis of diphosphoinositol polyphosphates is more than 85% less than that of the wild-type enzyme | Homo sapiens |
G52A | hydrolysis of diphosphoinositol polyphosphates is more than 85% less than that of the wild-type enzyme | Homo sapiens |
G72A | catalytic activity towards bisdiphosphoinositol tetrakisphosphate, diadenosine 5',5'''-P1,P6-hexaphosphateand diphosphoinositol pentakisphosphate is impaired by more than 95% | Homo sapiens |
G75A | catalytic activity towards bisdiphosphoinositol tetrakisphosphate, diadenosine 5',5'''-P1,P6-hexaphosphateand diphosphoinositol pentakisphosphate is impaired by more than 95% | Homo sapiens |
G78A | catalytic activity and CD spectrum is not significantly different from that of the wild.type enzyme | Homo sapiens |
G82A | mutation promotes some unraveling of the normal secondary structure | Homo sapiens |
H91L | hydrolysis of bisdiphosphoinositol tetrakisphosphate at 4% of the activity of the wild-type enzyme, hydrolysis of diadenosine 5',5'''-P1,P6-hexaphosphate is 26% of the activity of the wild-type enzyme, activity with diphosphoinositol pentakisphosphate is only slightly reduced | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
recombinant enzyme | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
bisdiphosphoinositol tetrakisphosphate + H2O | - |
Homo sapiens | ? + phosphate | - |
? | |
diadenosine 5',5''-P1,P6-hexaphosphate + H2O | - |
Homo sapiens | ? | - |
? | |
diphosphoinositol pentakisphosphate + H2O | - |
Homo sapiens | inositol hexakisphosphate + phosphate | - |
? |