Cloned (Comment) | Organism |
---|---|
genes Entpd1, 2, 3, 5, 6, and Entpd8 | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Mus musculus | - |
- |
membrane | - |
Mus musculus | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | required | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP + H2O | Mus musculus | - |
AMP + phosphate | - |
? | |
ATP + 2 H2O | Mus musculus | best substrate in hepatic stellate cells | AMP + 2 phosphate | - |
? | |
CDP + H2O | Mus musculus | - |
CMP + phosphate | - |
? | |
CTP + 2 H2O | Mus musculus | - |
CMP + 2 phosphate | - |
? | |
GTP + 2 H2O | Mus musculus | - |
GMP + 2 phosphate | - |
? | |
additional information | Mus musculus | substrate specificity in myofibroblasts and quiescent-like hepatic stellate cells, overview | ? | - |
? | |
UDP + H2O | Mus musculus | best substrate in myofibroblasts | UMP + phosphate | - |
? | |
UTP + 2 H2O | Mus musculus | - |
UMP + 2 phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
genes Entpd1, 2, 3, 5, 6, and Entpd8 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
GRX cell | hepatic stellate cell line. Both phenotypes of GRX cell line express NTPDase 3 and 5, but only activated cells express NTPDase 6, quantitative real-time PCR expression analysis of Entpd genes, overview | Mus musculus | - |
hepatic stellate cell | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
additional information | NTPs may be hydrolyzed mainly by NTPDase 3 in GRX cells and the increase in the NTPs hydrolysis observed in lipocytes is probably related to the up-regulation of Entpd3 mRNA expression | Mus musculus | - |
myofibroblast | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP + H2O | - |
Mus musculus | AMP + phosphate | - |
? | |
ATP + 2 H2O | - |
Mus musculus | AMP + 2 phosphate | - |
? | |
ATP + 2 H2O | best substrate in hepatic stellate cells | Mus musculus | AMP + 2 phosphate | - |
? | |
CDP + H2O | - |
Mus musculus | CMP + phosphate | - |
? | |
CTP + 2 H2O | - |
Mus musculus | CMP + 2 phosphate | - |
? | |
GTP + 2 H2O | - |
Mus musculus | GMP + 2 phosphate | - |
? | |
additional information | substrate specificity in myofibroblasts and quiescent-like hepatic stellate cells, overview | Mus musculus | ? | - |
? | |
UDP + H2O | - |
Mus musculus | UMP + phosphate | - |
? | |
UDP + H2O | best substrate in myofibroblasts | Mus musculus | UMP + phosphate | - |
? | |
UTP + 2 H2O | - |
Mus musculus | UMP + 2 phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
E-NTPDase 3 | - |
Mus musculus |
ecto-nucleoside triphosphate diphosphohydrolase | - |
Mus musculus |
NTPDase 3 | - |
Mus musculus |
NTPDase 5 | - |
Mus musculus |
NTPDase 6 | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |
General Information | Comment | Organism |
---|---|---|
evolution | the enzyme is a member of the E-NTPDase family | Mus musculus |
physiological function | ecto-nucleoside triphosphate diphosphohydrolases, E-NTPDases, regulate the concentration of extracellular nucleotides, signaling molecules that play a role in the pathogenesis of hepatic fibrosis. Up-regulation of Entpd3 mRNA expression modulates the extracellular concentration of nucleotides/nucleosides and affect P2-receptor signaling differently in quiescent-like cells and may play a role in the regulation of hepatic stellate cell functions | Mus musculus |