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Literature summary for 3.6.1.39 extracted from

  • Roscoe, D.H.
    Thymidine triphosphate nucleotidohydrolase: a phage-induced enzyme in Bacillus subtilis (1969), Virology, 38, 520-526.
    View publication on PubMed
Search for more literature for 3.6.1.39

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dTTP + H2O Bacillus subtilis
-
 dTDP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
 infected with phage phi
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dTTP + H2O
-
 Bacillus subtilis dTMP + diphosphate
-
 ?
dTTP + H2O
-
 Bacillus subtilis dTDP + phosphate
-
 ?
dUTP + H2O 70% activity compared with dTTP as substrate Bacillus subtilis dUMP + diphosphate
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
 Bacillus subtilis

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
-
-
 25% of activity compared with activity at 37°C Bacillus subtilis

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
50
-
 loss of activity in phage infected cells, no loss of activity in wild type cells Bacillus subtilis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
-
 Bacillus subtilis

pH Range

pH Minimum pH Maximum Comment Organism
7.5 10 measured in Tris-buffer and glycine-buffer Bacillus subtilis

pH Stability

pH Stability pH Stability Maximum Comment Organism
9
-
 loss of activity above pH 9 Bacillus subtilis