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Literature summary for 3.5.4.38 extracted from
- Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase (2015), Proc. Natl. Acad. Sci. USA, 112, 5791-5796 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9GZX7 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| CH12F3-2A cell | - |
Homo sapiens | - |
| HEK-293T cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AICDA | - |
Homo sapiens |
| AID | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | both heterogeneous nuclear ribonucleoproteins hnRNP K and L exhibit RNA-dependent interactions with AID and are required for antibody class switch recombination. Depletion of hnRNP K reduces somatic hypermutation, and hnRNP K is required for AID-induced DNA breaks | Homo sapiens |
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Release 2023.1 (January 2023)
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