Protein Variants | Comment | Organism |
---|---|---|
S38A | mutation does not impact catalytic activity, but interfers with class switching and somatic hypermutation in vivo | Mus musculus |
T140A | mutation does not impact catalytic activity, but interfers with class switching and somatic hypermutation in vivo | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cytosine in single-stranded DNA + H2O | Mus musculus | activation-induced cytidine deaminase (AID) is a mutator enzyme that initiates somatic mutation and class switch recombination in B lymphocytes by introducing uracil:guanine mismatches into DNA. Repair pathways process these mismatches to produce point mutations in the Ig variable region or double-stranded DNA breaks in the switch region DNA. The enzyme can also produce off-target DNA damage, including mutations in oncogenes | uracil in single-stranded DNA + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9WVE0 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | in addition to Ser38, the enzyme is also phosphorylated at position Thr140. Mutation of either Ser38 or Thr140 to Ala does not impact catalytic activity, but interfers with class switching and somatic hypermutation in vivo. Ser38 is equally important for both processes, Thr140 phosphorylation preferentially affects somatic mutation | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-lymphocyte | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cytosine in single-stranded DNA + H2O | - |
Mus musculus | uracil in single-stranded DNA + NH3 | - |
? | |
cytosine in single-stranded DNA + H2O | activation-induced cytidine deaminase (AID) is a mutator enzyme that initiates somatic mutation and class switch recombination in B lymphocytes by introducing uracil:guanine mismatches into DNA. Repair pathways process these mismatches to produce point mutations in the Ig variable region or double-stranded DNA breaks in the switch region DNA. The enzyme can also produce off-target DNA damage, including mutations in oncogenes | Mus musculus | uracil in single-stranded DNA + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
activation-induced cytidine deaminase | - |
Mus musculus |
AID | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | activation-induced cytidine deaminase (AID) is a mutator enzyme that initiates somatic mutation and class switch recombination in B lymphocytes by introducing uracil:guanine mismatches into DNA. Repair pathways process these mismatches to produce point mutations in the Ig variable region or double-stranded DNA breaks in the switch region DNA. The enzyme can also produce off-target DNA damage, including mutations in oncogenes | Mus musculus |