Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.5.3.4 extracted from

  • Scaraffia, P.Y.; Tan, G.; Isoe, J.; Wysocki, V.H.; Wells, M.A.; Miesfeld, R.L.
    Discovery of an alternate metabolic pathway for urea synthesis in adult Aedes aegypti mosquitoes (2008), Proc. Natl. Acad. Sci. USA, 105, 518-523.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.3.4

Activating Compound

Activating Compound Comment Organism Structure
additional information increased expression after blood meal at the end of digestion Aedes aegypti

Application

Application Comment Organism
pharmacology possibility to develop metabolism-based strategies for mosquito control Aedes aegypti

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
allantoate + H2O Aedes aegypti
-
 (S)-ureidoglycolate + urea
-
 ?
allantoate + H2O Aedes aegypti NH-Rockefeller
-
 (S)-ureidoglycolate + urea
-
 ?
allantoic acid + H2O Aedes aegypti
-
 ureidoglycolate + urea
-
 ?
allantoic acid + H2O Aedes aegypti NH-Rockefeller
-
 ureidoglycolate + urea
-
 ?

Organism

Organism UniProt Comment Textmining
Aedes aegypti A9XTM8 female mosquitoes
-
Aedes aegypti A9XTM8 NH-Rockefeller strain
-
Aedes aegypti NH-Rockefeller A9XTM8 NH-Rockefeller strain
-

Source Tissue

Source Tissue Comment Organism Textmining
fat body
-
 Aedes aegypti
-
fat body gene expression in, regulated after blood meal Aedes aegypti
-
feces feeding experiments, collection of feces and analysis by mass spectrometry Aedes aegypti
-
malpighian tubule
-
 Aedes aegypti
-
malpighian tubule gene expression in, regulated after blood meal Aedes aegypti
-
whole body kinetics of incorporation of labelled nitrogen Aedes aegypti
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 labelled uric acid metabolized to urea and excreted as nitrogenous waste through an uricolytic pathway, effect of intermediate products of the uricolytic pathway on urea synthesis analyzed by feeding mosquitoes with unlabeled intermediates, induced gene expression of allantoicase in response to blood meal feeding argues for a functional role of the uricolytic pathway in urea synthesis, significant increase in uric acid levels in whole-body extracts, reduction in labelled urea excretion Aedes aegypti

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
allantoate + H2O
-
 Aedes aegypti (S)-ureidoglycolate + urea
-
 ?
allantoate + H2O alternate metabolic pathway for urea synthesis, via an amphibian-like uricolytic pathway Aedes aegypti (S)-ureidoglycolate + urea
-
 ?
allantoate + H2O
-
 Aedes aegypti NH-Rockefeller (S)-ureidoglycolate + urea
-
 ?
allantoate + H2O alternate metabolic pathway for urea synthesis, via an amphibian-like uricolytic pathway Aedes aegypti NH-Rockefeller (S)-ureidoglycolate + urea
-
 ?
allantoic acid + H2O
-
 Aedes aegypti ureidoglycolate + urea
-
 ?
allantoic acid + H2O alternate metabolic pathway for urea synthesis, via an amphibian-like uricolytic pathway Aedes aegypti ureidoglycolate + urea
-
 ?
allantoic acid + H2O
-
 Aedes aegypti NH-Rockefeller ureidoglycolate + urea
-
 ?
allantoic acid + H2O alternate metabolic pathway for urea synthesis, via an amphibian-like uricolytic pathway Aedes aegypti NH-Rockefeller ureidoglycolate + urea
-
 ?

Synonyms

Synonyms Comment Organism
AaALLC
-
 Aedes aegypti
allantoicase
-
 Aedes aegypti
ALLC
-
 Aedes aegypti