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Literature summary for 3.5.3.18 extracted from

  • Shiozawa, T.; Iyama, S.; Toshima, S.; Sakata, A.; Usui, S.; Minami, Y.; Sato, Y.; Hizawa, N.; Noguchi, M.
    Dimethylarginine dimethylaminohydrolase 2 promotes tumor angiogenesis in lung adenocarcinoma (2016), Virchows Arch., 468, 179-190 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine in lung adenocarcinoma, isoform DDAH2 is expressed in fibroblasts of stroma of malignancies, with higher expression in minimally invasive adenocarcinoma and invasive adenocarcinoma than in adenocarcinoma in situ. Tumors with high stromal expression of DDAH2 have a poorer prognosis than those without Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O95865
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Source Tissue

Source Tissue Comment Organism Textmining
adenocarcinoma cell
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 Homo sapiens
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lung
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 Homo sapiens
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General Information

General Information Comment Organism
physiological function DDAH2 increases expression of endothelial nitric oxide synthase (eNOS), inducing proliferation and capillary-like tube formation of vascular endothelial cells. eNOS shows higher expression in invasive adenocarcinoma than in adenocarcinoma in situ and normal lung, similarly to DDAH2 Homo sapiens