Literature summary for 3.5.3.15 extracted from

Arita, K.; Hashimoto, H.; Shimizu, T.; Nakashima, K.; Yamada, M.; Sato, M.
Structural basis for Ca2+-induced activation of human PAD4 (2004), Nat. Struct. Mol. Biol., 11, 777-783.

Search for more literature for 3.5.3.15

Crystallization (Commentary)

Crystallization (Comment)	Organism
Ca2+-free enzyme	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
C645A	no enzymic activity, catalytic residue	Homo sapiens
D350A	no enzymic activity, catalytic residue	Homo sapiens
D369A	no enzymic activity, ligand for Ca2 coordination	Homo sapiens
D388A	81% of wild type activity, ligand for Ca4 coordination	Homo sapiens
D473A	no enzymic activity, catalytic residue	Homo sapiens
E351A	33% of wild type activity, ligand for Ca2 coordination	Homo sapiens
E353A	no enzymic activity, ligand for Ca1 coordination	Homo sapiens
E411A	no enzymic activity, ligand for Ca1 coordination	Homo sapiens
H471A	no enzymic activity, catalytic residue	Homo sapiens
N373A	no enzymic activity, ligand for Ca2 coordination	Homo sapiens
N648A	37% of wild type activity, ligand for water-mediated Ca1 coordination	Homo sapiens
Q349A	no enzymic activity, ligand for Ca1 coordination	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	five binding sites, Ca2+-binding induces conformational changes	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9UM07	enzyme isoform PAD4	-

Synonyms

Synonyms	Comment	Organism
PAD4	-	Homo sapiens

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Release 2023.1 (January 2023)