Literature summary for 3.5.2.5 extracted from

Nourimand, M.; Todd, C.D.
There is a direct link between allantoin concentration and cadmium tolerance in Arabidopsis (2019), Plant Physiol. Biochem., 135, 441-449 .

Search for more literature for 3.5.2.5

Cloned(Commentary)

Cloned (Comment)	Organism
gene ALN, quantitative RT-PCR enzyme expression analysis	Arabidopsis thaliana

Protein Variants

Protein Variants	Comment	Organism
additional information	generation of ALN-overexpressing (ALNox) lines. in ALNox lines the ALN gene expression increase leads to increased enzyme activity and suppressed allantoin accumulation. Therefore, ALNox Arabidopsis thaliana lines exhibit the opposite phenotype in comparison with aln-3 mutants, namely sensitivity to abiotic stress. The aln-3 enzyme-deficient mutant lines exhibit increased Cd tolerance	Arabidopsis thaliana

Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	Q94AP0	-	-
Arabidopsis thaliana Col-0	Q94AP0	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
seed	-	Arabidopsis thaliana	-

General Information

General Information	Comment	Organism
malfunction	ALN-overexpressing (ALNox) lines. in ALNox lines the ALN gene expression increase leads to increased enzyme activity and suppressed allantoin accumulation. Therefore, ALNox Arabidopsis thaliana lines exhibit the opposite phenotype in comparison with aln-3 mutants, namely sensitivity sto abiotic stress. The aln-3 enzyme-deficient mutant lines exhibit increased Cd tolerance	Arabidopsis thaliana
metabolism	allantoin treatment of wild-type Col-0 seeds increases superoxide dismutase activity causing an enhanced seed germination and seedling growth following Cd exposure. Allantoinase-overexpressing (ALNox) lines with lower levels of allantoin exhibit more susceptibility to Cd treatment than wild-type Arabidopsis thaliana, implying that there is a positive correlation between allantoin concentration and Cd resistance in plants. The potential regulatory function of allantoin does not require abscisic acid (ABA) at germination but may be ABA-dependent at later stages of seedling growth, suggesting a potential crosstalk between allantoin-mediated stress response and ABA signalling pathway in plants. Protective role for allantoin at early stages of seedling growth. Increased allantoin concentration (both in vivo and in vitro) causes Cd-tolerance in plants	Arabidopsis thaliana

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Release 2023.1 (January 2023)