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Literature summary for 3.5.1.99 extracted from

  • Sunduru, N.; Svensson, M.; Cipriano, M.; Marwaha, S.; Andersson, C.D.; Svensson, R.; Fowler, C.J.; Elofsson, M.
    N-aryl 2-aryloxyacetamides as a new class of fatty acid amide hydrolase (FAAH) inhibitors (2017), J. Enzyme Inhib. Med. Chem., 32, 513-521 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.99

Application

Application Comment Organism
medicine fatty acid amide hydrolase is a promising target for the development of drugs to treat neurological diseases Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
2-(4-cyclohexylphenoxy)-N-[2-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
 Rattus norvegicus
2-(4-cyclohexylphenoxy)-N-[3-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
 Rattus norvegicus
2-(4-cyclohexylphenoxy)-N-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
 Rattus norvegicus
2-(4-cyclohexylphenoxy)-N-[4-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
 Rattus norvegicus
2-(4-cyclohexylphenoxy)-N-[4-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
 Rattus norvegicus
2-[([1,1'-biphenyl]-4-yl)oxy]-N-[2-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
 Rattus norvegicus
2-[([1,1'-biphenyl]-4-yl)oxy]-N-[3-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
 Rattus norvegicus
2-[([1,1'-biphenyl]-4-yl)oxy]-N-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
 Rattus norvegicus
2-[([1,1'-biphenyl]-4-yl)oxy]-N-[4-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
 Rattus norvegicus
2-[[(2E)-hex-2-en-1-yl]oxy]-N-[2-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
 Rattus norvegicus
2-[[(2E)-hex-2-en-1-yl]oxy]-N-[3-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
 Rattus norvegicus
2-[[(2E)-hex-2-en-1-yl]oxy]-N-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
 Rattus norvegicus
2-[[(2E)-hex-2-en-1-yl]oxy]-N-[4-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
-
 Rattus norvegicus
N-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]-2-phenoxyacetamide
-
 Rattus norvegicus
N-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]-2-[4-(propan-2-yl)phenoxy]acetamide
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P97612
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-arachidonoylethanolamine + H2O
-
 Rattus norvegicus arachidonic acid + ethanolamine
-
 ?

Synonyms

Synonyms Comment Organism
FAAH
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00035
-
 assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication Rattus norvegicus 2-(4-cyclohexylphenoxy)-N-[4-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]acetamide
0.00062
-
 assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication Rattus norvegicus 2-[([1,1'-biphenyl]-4-yl)oxy]-N-[4-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
0.00063
-
 assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication Rattus norvegicus 2-[([1,1'-biphenyl]-4-yl)oxy]-N-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]acetamide
0.00065
-
 assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication Rattus norvegicus 2-(4-cyclohexylphenoxy)-N-[2-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
0.0011
-
 assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication Rattus norvegicus 2-[([1,1'-biphenyl]-4-yl)oxy]-N-[2-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
0.0015
-
 assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication Rattus norvegicus 2-(4-cyclohexylphenoxy)-N-[4-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
0.0021
-
 assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication Rattus norvegicus N-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]-2-[4-(propan-2-yl)phenoxy]acetamide
0.0026
-
 assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication Rattus norvegicus 2-(4-cyclohexylphenoxy)-N-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]acetamide
0.0055
-
 assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication Rattus norvegicus 2-[[(2E)-hex-2-en-1-yl]oxy]-N-[2-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
0.013
-
 assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication Rattus norvegicus 2-[([1,1'-biphenyl]-4-yl)oxy]-N-[3-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
0.017
-
 assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication Rattus norvegicus 2-[[(2E)-hex-2-en-1-yl]oxy]-N-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]acetamide
0.018
-
 assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication Rattus norvegicus N-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]-2-phenoxyacetamide
0.047
-
 assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication Rattus norvegicus 2-(4-cyclohexylphenoxy)-N-[3-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
0.064
-
 assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication Rattus norvegicus 2-[[(2E)-hex-2-en-1-yl]oxy]-N-[4-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide
0.073
-
 assay in brain homogenates, substrate ananamide, pH and temperature not specified in the publication Rattus norvegicus 2-[[(2E)-hex-2-en-1-yl]oxy]-N-[3-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl]acetamide