Cloned (Comment) | Organism |
---|---|
gene VNN2, semiquantitative RT-PCR expression analysis in ovulatory follicles and granulosa cells, DNA-binding activity of bovine VNN2 promoter, overview | Bos taurus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of several VNN2 promoter-deletion mutants: deletion of the region between -1107 and -530 result in a marked and significant increase of basal and forskolin-stimulated promoter activities, suggesting factors repressing the promoter activity in this region. This region contains a number of consensus cis-acting elements of which COUP-TF, GATA, and Ebox appears to play a key role, as revealed by site-directed mutagenesis and promoter activity assays. Deletion between -530 and -262 markedly decreased basal and forskolin-stimulated promoter activities as compared to the-530VNN2.LUC construct. Further deletions do not change promoter activities, thus identifying the region -530/-262 as important in the regulation of the VNN2 promoter activity in bovine granulosa cells | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | A5D9D1 | - |
- |
Bos taurus Holstein | A5D9D1 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
granulosa cell | regulation of VNN2 transcripts in bovine follicles prior to ovulation, high levels of gonadotropins regulate VNN2 mRNA expression in granulosa cells of bovine preovulatory follicles | Bos taurus | - |
ovarian follicle | ovulatory, regulation of VNN2 transcripts in bovine follicles prior to ovulation, high expression level during the ovulatory process | Bos taurus | - |
Synonyms | Comment | Organism |
---|---|---|
vanin-2 | - |
Bos taurus |
VNN2 | - |
Bos taurus |
Organism | Comment | Expression |
---|---|---|
Bos taurus | VNN2 promoter activity and mRNA expression are inhibited by protein kinase A and ERK1/2 inhibitors | down |
Bos taurus | VNN2 promoter activity and mRNA expression are markedly stimulated by forskolin and overexpression of the catalytic subunit of protein kinase A | up |
General Information | Comment | Organism |
---|---|---|
physiological function | vanin-2 is known to be involved in inflammation and leukocyte migration | Bos taurus |