Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mus musculus | 16020 | - |
membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-O-[N-acetyl-alpha-D-glucosaminyl]-1-octadecylphospho-1D-myo-inositol + H2O | Homo sapiens | - |
6-O-alpha-D-glucosaminyl-1-octadecylphospho-1D-myo-inositol + acetate | - |
? | |
6-O-[N-acetyl-alpha-D-glucosaminyl]-1-[1,2-bis(hexadecanoyl)-sn-glycero]phospho-1D-myo-inositol + H2O | Homo sapiens | - |
6-O-alpha-D-glucosaminyl-1-[1,2-bis(hexadecanoyl)-sn-glycero]phospho-1D-myo-inositol + acetate | - |
? | |
pantetheine + H2O | Mus musculus | - |
pantothenate + cysteamine | - |
? | |
pantetheine + H2O | Homo sapiens | - |
pantothenate + cysteamine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
intestine | - |
Mus musculus | - |
intestine | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
leukocyte | peripheral blood leukocyte | Homo sapiens | - |
liver | - |
Mus musculus | - |
liver | - |
Homo sapiens | - |
lymph node | - |
Homo sapiens | - |
renal epithelium | - |
Mus musculus | - |
respiratory system | - |
Homo sapiens | - |
spleen | - |
Homo sapiens | - |
thymus | - |
Homo sapiens | - |
urethra | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-O-[N-acetyl-alpha-D-glucosaminyl]-1-octadecylphospho-1D-myo-inositol + H2O | - |
Homo sapiens | 6-O-alpha-D-glucosaminyl-1-octadecylphospho-1D-myo-inositol + acetate | - |
? | |
6-O-[N-acetyl-alpha-D-glucosaminyl]-1-[1,2-bis(hexadecanoyl)-sn-glycero]phospho-1D-myo-inositol + H2O | - |
Homo sapiens | 6-O-alpha-D-glucosaminyl-1-[1,2-bis(hexadecanoyl)-sn-glycero]phospho-1D-myo-inositol + acetate | - |
? | |
pantetheine + H2O | - |
Mus musculus | pantothenate + cysteamine | - |
? | |
pantetheine + H2O | - |
Homo sapiens | pantothenate + cysteamine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
pantetheinase | - |
Mus musculus |
pantetheinase | - |
Homo sapiens |
vanin 1 | - |
Mus musculus |
vanin 1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | vanin 1 knockout mice display an enhanced resistance to oxidative stress and show down-regulated tissue inflammation in response to oxidative stress. Vanin knockout mice exhibit a loss of cysteamine-mediated inhibition of peroxisome proliferator-activated receptor gamma. Vanin 1 deficient islets are twice as susceptible to cell death as wild type cells | Mus musculus |
physiological function | vanin plays a role in inflammation, oxidative stress, cell migration and numerous diseases including cardiovascular disease (increased vanin 1 activity has a protective effect against cardiovascular disease). Vanin 1 has a cytoprotective effect against type 1 diabetes in islet cells. Vanin 1 is a central regulator of not only stress responses via production of cysteamine but also lipid biosynthesis by controlling the flux through the fatty acid and/or cholesterol biosynthetic pathways | Mus musculus |
physiological function | vanin plays a role in inflammation, oxidative stress, cell migration and numerous diseases including cardiovascular disease (increased vanin 1 activity has a protective effect against cardiovascular disease). Vanin 1 has a cytoprotective effect against type 1 diabetes in islet cells. Vanin 1 is a central regulator of not only stress responses via production of cysteamine but also lipid biosynthesis by controlling the flux through the fatty acid and/or cholesterol biosynthetic pathways | Homo sapiens |