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Literature summary for 3.5.1.92 extracted from

  • Kaskow, B.J.; Michael Proffit, J.; Blangero, J.; Moses, E.K.; Abraham, L.J.
    Diverse biological activities of the vascular non-inflammatory molecules - the Vanin pantetheinases (2012), Biochem. Biophys. Res. Commun., 417, 653-658.
    View publication on PubMed
Search for more literature for 3.5.1.92

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Mus musculus 16020
-
membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-O-[N-acetyl-alpha-D-glucosaminyl]-1-octadecylphospho-1D-myo-inositol + H2O Homo sapiens
-
 6-O-alpha-D-glucosaminyl-1-octadecylphospho-1D-myo-inositol + acetate
-
 ?
6-O-[N-acetyl-alpha-D-glucosaminyl]-1-[1,2-bis(hexadecanoyl)-sn-glycero]phospho-1D-myo-inositol + H2O Homo sapiens
-
 6-O-alpha-D-glucosaminyl-1-[1,2-bis(hexadecanoyl)-sn-glycero]phospho-1D-myo-inositol + acetate
-
 ?
pantetheine + H2O Mus musculus
-
 pantothenate + cysteamine
-
 ?
pantetheine + H2O Homo sapiens
-
 pantothenate + cysteamine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
 Mus musculus
-
intestine
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
leukocyte peripheral blood leukocyte Homo sapiens
-
liver
-
 Mus musculus
-
liver
-
 Homo sapiens
-
lymph node
-
 Homo sapiens
-
renal epithelium
-
 Mus musculus
-
respiratory system
-
 Homo sapiens
-
spleen
-
 Homo sapiens
-
thymus
-
 Homo sapiens
-
urethra
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-O-[N-acetyl-alpha-D-glucosaminyl]-1-octadecylphospho-1D-myo-inositol + H2O
-
 Homo sapiens 6-O-alpha-D-glucosaminyl-1-octadecylphospho-1D-myo-inositol + acetate
-
 ?
6-O-[N-acetyl-alpha-D-glucosaminyl]-1-[1,2-bis(hexadecanoyl)-sn-glycero]phospho-1D-myo-inositol + H2O
-
 Homo sapiens 6-O-alpha-D-glucosaminyl-1-[1,2-bis(hexadecanoyl)-sn-glycero]phospho-1D-myo-inositol + acetate
-
 ?
pantetheine + H2O
-
 Mus musculus pantothenate + cysteamine
-
 ?
pantetheine + H2O
-
 Homo sapiens pantothenate + cysteamine
-
 ?

Synonyms

Synonyms Comment Organism
pantetheinase
-
 Mus musculus
pantetheinase
-
 Homo sapiens
vanin 1
-
 Mus musculus
vanin 1
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction vanin 1 knockout mice display an enhanced resistance to oxidative stress and show down-regulated tissue inflammation in response to oxidative stress. Vanin knockout mice exhibit a loss of cysteamine-mediated inhibition of peroxisome proliferator-activated receptor gamma. Vanin 1 deficient islets are twice as susceptible to cell death as wild type cells Mus musculus
physiological function vanin plays a role in inflammation, oxidative stress, cell migration and numerous diseases including cardiovascular disease (increased vanin 1 activity has a protective effect against cardiovascular disease). Vanin 1 has a cytoprotective effect against type 1 diabetes in islet cells. Vanin 1 is a central regulator of not only stress responses via production of cysteamine but also lipid biosynthesis by controlling the flux through the fatty acid and/or cholesterol biosynthetic pathways Mus musculus
physiological function vanin plays a role in inflammation, oxidative stress, cell migration and numerous diseases including cardiovascular disease (increased vanin 1 activity has a protective effect against cardiovascular disease). Vanin 1 has a cytoprotective effect against type 1 diabetes in islet cells. Vanin 1 is a central regulator of not only stress responses via production of cysteamine but also lipid biosynthesis by controlling the flux through the fatty acid and/or cholesterol biosynthetic pathways Homo sapiens