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Literature summary for 3.5.1.4 extracted from

  • Eichhorn, E.; Roduit, J.P.; Shaw, N.; Heinzmann, K.; Kiener, A.
    Preparation of (S)-piperazine-2-carboxylic acid, (R)-piperazine-2-carboxylic acid, and (S)-pipecolic acid by kinetic resolution of the corresponding racemic carboxamides with stereoselective amidase in whole bacterial cells (1997), Tetrahedron Asymmetry, 8, 2533-2536.
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Application

Application Comment Organism
synthesis production of (S)-piperazine-2-carboxylic acid, which is used as an intermediate for pharmaceuticals, e.g. the orally active HIV protease inhibitor crixican Raoultella terrigena

Organism

Organism UniProt Comment Textmining
Raoultella terrigena
-
 DSM 9174
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R/S)-piperazine-2-carboxamide + H2O
-
 Raoultella terrigena (S)-piperazine-2-carboxylic acid + (R)-piperazine-2-carboxamide
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
47
-
-
 Raoultella terrigena

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
 Raoultella terrigena