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Literature summary for 3.5.1.25 extracted from

  • Popowska, M.; Osinska, M.; Rzeczkowska, M.
    N-acetylglucosamine-6-phosphate deacetylase (NagA) of Listeria monocytogenes EGD, an essential enzyme for the metabolism and recycling of amino sugars (2012), Arch. Microbiol., 194, 255-268.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.25

Cloned(Commentary)

Cloned (Comment) Organism
gene lmo0956, genetic organization, phylogenetic analysis Listeria monocytogenes
gene lmo2108, genetic organization, phylogenetic analysis Listeria monocytogenes

Protein Variants

Protein Variants Comment Organism
additional information knockout of gene lmo0956, phenotype, overview Listeria monocytogenes
additional information knockout of gene lmo1208, phenotype, overview Listeria monocytogenes

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Listeria monocytogenes 5737
-
cytosol
-
 Listeria monocytogenes 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-acetyl-D-glucosamine 6-phosphate + H2O Listeria monocytogenes
-
 D-glucosamine 6-phosphate + acetate
-
 ?

Organism

Organism UniProt Comment Textmining
Listeria monocytogenes Q8Y5F6 gene lmo2108
-
Listeria monocytogenes Q8Y8E8
-
-
Listeria monocytogenes Q8Y8E8 gene lmo0956
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-D-glucosamine 6-phosphate + H2O
-
 Listeria monocytogenes D-glucosamine 6-phosphate + acetate
-
 ?

Synonyms

Synonyms Comment Organism
Lmo0956
-
 Listeria monocytogenes
Lmo0956 protein protein with N-acetylglucosamine-6-phosphate de-N-acetylase domain Listeria monocytogenes
Lmo2108
-
 Listeria monocytogenes
Lmo2108 protein protein with N-acetylglucosamine-6-phosphate de-N-acetylase domain Listeria monocytogenes
N-acetylglucosamine-6-P deacetylase
-
 Listeria monocytogenes
N-acetylglucosamine-6-phosphate de-N-acetylase
-
 Listeria monocytogenes
NagA
-
 Listeria monocytogenes

General Information

General Information Comment Organism
malfunction mutants deficient in protein Lmo0956 reveal strikingly altered cell morphology, strongly reduced cell wall murein content and decreased sensitivity to cell wall hydrolase, mutanolysin and peptide antibiotic, colistin Listeria monocytogenes
metabolism gene products of operon 150, consisting of three genes: lmo0956, lmo0957, and lmo0958, are necessary for the cytosolic steps of the amino-sugar-recycling pathway. The reverse reaction to Glc-N-6-P is catalyzed by GlmS Listeria monocytogenes
additional information enzyme structure modeling, overview Listeria monocytogenes
physiological function Lmo0956 protein is required for cell wall peptidoglycan and teichoic acid biosynthesis and is essential for bacterial cell growth, cell division, and sensitivity to cell wall hydrolases and peptide antibiotics. Lmo0956 and Lmo2108 are involved in the deacetylation of muropeptides that have been taken up into the bacterial cell Listeria monocytogenes
physiological function cytoplasmic de-N-acetylase Lmo0956 is required for cell wall peptidoglycan and teichoic acid biosynthesis and is also essential for bacterial cell growth, cell division, and sensitivity to cell wall hydrolases and peptide antibiotics Listeria monocytogenes