Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of deletion mutant BtDELTABtD2086, that is catalytically inactive. Using isogenic strains of wild-type and BSH-deleted Bacteroides thetaiotaomicron, the levels of the bile acid tauro-beta-muricholic acid in monocolonized gnotobiotic mice are selectively modulated. Bacteroides thetaiotaomicron BSH mutant-colonized mice display altered metabolism, including reduced weight gain and respiratory exchange ratios, as well as transcriptional changes in metabolic, circadian rhythm, and immune pathways in the gut and liver | Bacteroides thetaiotaomicron |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
glycochenodeoxycholic acid + H2O | Bacteroides thetaiotaomicron | low activity | chenodeoxycholate + glycine | - |
? | |
glycochenodeoxycholic acid + H2O | Bacteroides thetaiotaomicron VPI-5482 | low activity | chenodeoxycholate + glycine | - |
? | |
glycodeoxycholic acid + H2O | Bacteroides thetaiotaomicron | high activity | deoxycholate + glycine | - |
? | |
glycodeoxycholic acid + H2O | Bacteroides thetaiotaomicron VPI-5482 | high activity | deoxycholate + glycine | - |
? | |
glycolithocholic acid + H2O | Bacteroides thetaiotaomicron | preferred substrate | lithocholate + glycine | - |
? | |
glycoursodeoxycholic acid + H2O | Bacteroides thetaiotaomicron | moderate activity | ursodeoxycholate + glycine | - |
? | |
additional information | Bacteroides thetaiotaomicron | comparisons of substrate specificity and selective BSH activity in the human gut bacterial phylum Bacteroidetes, overview | ? | - |
? | |
additional information | Bacteroides thetaiotaomicron VPI-5482 | comparisons of substrate specificity and selective BSH activity in the human gut bacterial phylum Bacteroidetes, overview | ? | - |
? | |
tauro-beta-muricholic acid + H2O | Bacteroides thetaiotaomicron | - |
beta-muricholate + taurine | - |
? | |
taurodeoxycholic acid + H2O | Bacteroides thetaiotaomicron | high activity | deoxycholate + taurine | - |
? | |
taurolithocholic acid + H2O | Bacteroides thetaiotaomicron | preferred substrate | lithocholate + taurine | - |
? | |
tauroursodeoxycholic acid + H2O | Bacteroides thetaiotaomicron | moderate activity | ursodeoxycholate + taurine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacteroides thetaiotaomicron | - |
- |
- |
Bacteroides thetaiotaomicron VPI-5482 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glycochenodeoxycholic acid + H2O | low activity | Bacteroides thetaiotaomicron | chenodeoxycholate + glycine | - |
? | |
glycochenodeoxycholic acid + H2O | low activity | Bacteroides thetaiotaomicron VPI-5482 | chenodeoxycholate + glycine | - |
? | |
glycodeoxycholic acid + H2O | high activity | Bacteroides thetaiotaomicron | deoxycholate + glycine | - |
? | |
glycodeoxycholic acid + H2O | high activity | Bacteroides thetaiotaomicron VPI-5482 | deoxycholate + glycine | - |
? | |
glycolithocholic acid + H2O | preferred substrate | Bacteroides thetaiotaomicron | lithocholate + glycine | - |
? | |
glycoursodeoxycholic acid + H2O | moderate activity | Bacteroides thetaiotaomicron | ursodeoxycholate + glycine | - |
? | |
additional information | comparisons of substrate specificity and selective BSH activity in the human gut bacterial phylum Bacteroidetes, overview | Bacteroides thetaiotaomicron | ? | - |
? | |
additional information | selectivity for deconjugating C12 = H but not C12 = OH core primary bile acids. No activity with glycocholic acid and taurocholic acid, taurochenodeoxycholic acid is a poor substrate | Bacteroides thetaiotaomicron | ? | - |
? | |
additional information | comparisons of substrate specificity and selective BSH activity in the human gut bacterial phylum Bacteroidetes, overview | Bacteroides thetaiotaomicron VPI-5482 | ? | - |
? | |
additional information | selectivity for deconjugating C12 = H but not C12 = OH core primary bile acids. No activity with glycocholic acid and taurocholic acid, taurochenodeoxycholic acid is a poor substrate | Bacteroides thetaiotaomicron VPI-5482 | ? | - |
? | |
tauro-beta-muricholic acid + H2O | i.e. TbetaMCA, synthetic fluorogenic substrate of BSH | Bacteroides thetaiotaomicron | taurine + beta-muricholic acid | - |
? | |
tauro-beta-muricholic acid + H2O | i.e. TbetaMCA, synthetic fluorogenic substrate of BSH | Bacteroides thetaiotaomicron VPI-5482 | taurine + beta-muricholic acid | - |
? | |
tauro-beta-muricholic acid + H2O | - |
Bacteroides thetaiotaomicron | beta-muricholate + taurine | - |
? | |
taurodeoxycholic acid + H2O | high activity | Bacteroides thetaiotaomicron | deoxycholate + taurine | - |
? | |
taurolithocholic acid + H2O | preferred substrate | Bacteroides thetaiotaomicron | lithocholate + taurine | - |
? | |
tauroursodeoxycholic acid + H2O | moderate activity | Bacteroides thetaiotaomicron | ursodeoxycholate + taurine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
bile salt hydrolase | - |
Bacteroides thetaiotaomicron |
BSH | - |
Bacteroides thetaiotaomicron |
BT2086 | - |
Bacteroides thetaiotaomicron |
General Information | Comment | Organism |
---|---|---|
malfunction | using isogenic strains of wild-type and BSH-deleted Bacteroides thetaiotaomicron, the levels of the bile acid tauro-beta-muricholic acid in monocolonized gnotobiotic mice are selectively modulated. Bacteroides thetaiotaomicron BSH mutant-colonized mice display altered metabolism, including reduced weight gain and respiratory exchange ratios, as well as transcriptional changes in metabolic, circadian rhythm, and immune pathways in the gut and liver | Bacteroides thetaiotaomicron |