BRENDA - Enzyme Database
show all sequences of 3.5.1.23

Purification and biochemical characterization of membrane-bound neutral ceramidase from camel brain (Camelus dromedarius)

Chathoth, S.; Thayyullathil, F.; Galadari, A.; Patel, M.; Galadari, S.; Int. J. Biochem. Mol. Biol. 4, 54-66 (2013)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
ADP
-
Camelus dromedarius
Cu2+
-
Camelus dromedarius
cysteine
-
Camelus dromedarius
GSH
-
Camelus dromedarius
GSSG
-
Camelus dromedarius
N-acetylcysteine
-
Camelus dromedarius
phosphatidic acid
complete inhibition
Camelus dromedarius
phosphatidylcholine
complete inhibition
Camelus dromedarius
phosphatidylserine
complete inhibition
Camelus dromedarius
TMP
-
Camelus dromedarius
UMP
-
Camelus dromedarius
Zn2+
-
Camelus dromedarius
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
Michaelis-Menten kinetics
Camelus dromedarius
0.0498
-
C12-NBD-Cer
pH 7.5, 37°C
Camelus dromedarius
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
membrane
membrane-bound
Camelus dromedarius
16020
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Ca2+
activates
Camelus dromedarius
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
80000
-
x * 100000, about, glycosylated enzyme, SDS-PAGE, x * 80000, about, deglycosylated enzyme, SDS-PAGE
Camelus dromedarius
100000
-
x * 100000, about, glycosylated enzyme, SDS-PAGE, x * 80000, about, deglycosylated enzyme, SDS-PAGE
Camelus dromedarius
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Camelus dromedarius
-
-
-
Posttranslational Modification
Posttranslational Modification
Commentary
Organism
glycoprotein
deeglycosylation by glycosidase F treatment
Camelus dromedarius
Purification (Commentary)
Commentary
Organism
native enzyme 2147.1fold from brain to homogeneity by anion exchange and hydrophobic interaction chromtography, gel filtration, and another step of anion exchange chromatography
Camelus dromedarius
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
-
Camelus dromedarius
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
230.6
-
purified enzyme, pH 7.5, 37°C
Camelus dromedarius
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
C12-NBD-Cer + H2O
the enzyme catalyzes also the reverse reaction of ceramide synthesis
733984
Camelus dromedarius
NBD-dodecanoic acid + D-erythro-sphingosine
-
-
-
r
N-hexanoyl-D-erythro-sphingosine + H2O
-
733984
Camelus dromedarius
hexanoate + D-erythro-sphingosine
-
-
-
?
N-lauroyl-D-erythro-sphingosine + H2O
the enzyme catalyzes also the reverse reaction of ceramide synthesis
733984
Camelus dromedarius
laurate + D-erythro-sphingosine
-
-
-
r
N-lignoceroyl-D-erythro-sphingosine + H2O
low activity
733984
Camelus dromedarius
lignocerate + D-erythro-sphingosine
-
-
-
?
N-myristoyl-D-erythro-sphingosine + H2O
best substrate
733984
Camelus dromedarius
myristate + D-erythro-sphingosine
-
-
-
?
N-palmitoyl-D-erythro-sphingosine + H2O
-
733984
Camelus dromedarius
palmitate + D-erythro-sphingosine
-
-
-
?
N-stearoyl-D-erythro-sphingosine + H2O
-
733984
Camelus dromedarius
stearate + D-erythro-sphingosine
-
-
-
?
Subunits
Subunits
Commentary
Organism
?
x * 100000, about, glycosylated enzyme, SDS-PAGE, x * 80000, about, deglycosylated enzyme, SDS-PAGE
Camelus dromedarius
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Camelus dromedarius
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
-
-
Camelus dromedarius
pH Range
pH Minimum
pH Maximum
Commentary
Organism
4
10
activity range, high activity at pH 6.0-8.0, profile overview
Camelus dromedarius
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
ADP
-
Camelus dromedarius
Cu2+
-
Camelus dromedarius
cysteine
-
Camelus dromedarius
GSH
-
Camelus dromedarius
GSSG
-
Camelus dromedarius
N-acetylcysteine
-
Camelus dromedarius
phosphatidic acid
complete inhibition
Camelus dromedarius
phosphatidylcholine
complete inhibition
Camelus dromedarius
phosphatidylserine
complete inhibition
Camelus dromedarius
TMP
-
Camelus dromedarius
UMP
-
Camelus dromedarius
Zn2+
-
Camelus dromedarius
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
Michaelis-Menten kinetics
Camelus dromedarius
0.0498
-
C12-NBD-Cer
pH 7.5, 37°C
Camelus dromedarius
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
membrane
membrane-bound
Camelus dromedarius
16020
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Ca2+
activates
Camelus dromedarius
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
80000
-
x * 100000, about, glycosylated enzyme, SDS-PAGE, x * 80000, about, deglycosylated enzyme, SDS-PAGE
Camelus dromedarius
100000
-
x * 100000, about, glycosylated enzyme, SDS-PAGE, x * 80000, about, deglycosylated enzyme, SDS-PAGE
Camelus dromedarius
Posttranslational Modification (protein specific)
Posttranslational Modification
Commentary
Organism
glycoprotein
deeglycosylation by glycosidase F treatment
Camelus dromedarius
Purification (Commentary) (protein specific)
Commentary
Organism
native enzyme 2147.1fold from brain to homogeneity by anion exchange and hydrophobic interaction chromtography, gel filtration, and another step of anion exchange chromatography
Camelus dromedarius
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
-
Camelus dromedarius
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
230.6
-
purified enzyme, pH 7.5, 37°C
Camelus dromedarius
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
C12-NBD-Cer + H2O
the enzyme catalyzes also the reverse reaction of ceramide synthesis
733984
Camelus dromedarius
NBD-dodecanoic acid + D-erythro-sphingosine
-
-
-
r
N-hexanoyl-D-erythro-sphingosine + H2O
-
733984
Camelus dromedarius
hexanoate + D-erythro-sphingosine
-
-
-
?
N-lauroyl-D-erythro-sphingosine + H2O
the enzyme catalyzes also the reverse reaction of ceramide synthesis
733984
Camelus dromedarius
laurate + D-erythro-sphingosine
-
-
-
r
N-lignoceroyl-D-erythro-sphingosine + H2O
low activity
733984
Camelus dromedarius
lignocerate + D-erythro-sphingosine
-
-
-
?
N-myristoyl-D-erythro-sphingosine + H2O
best substrate
733984
Camelus dromedarius
myristate + D-erythro-sphingosine
-
-
-
?
N-palmitoyl-D-erythro-sphingosine + H2O
-
733984
Camelus dromedarius
palmitate + D-erythro-sphingosine
-
-
-
?
N-stearoyl-D-erythro-sphingosine + H2O
-
733984
Camelus dromedarius
stearate + D-erythro-sphingosine
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 100000, about, glycosylated enzyme, SDS-PAGE, x * 80000, about, deglycosylated enzyme, SDS-PAGE
Camelus dromedarius
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Camelus dromedarius
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
-
-
Camelus dromedarius
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
4
10
activity range, high activity at pH 6.0-8.0, profile overview
Camelus dromedarius
Other publictions for EC 3.5.1.23
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
733093
Pizzirani
Benzoxazolone carboxamides: po ...
Homo sapiens, Mus musculus
Angew. Chem. Int. Ed. Engl.
54
485-489
2015
-
2
-
-
-
-
8
-
-
-
-
2
-
2
-
-
-
-
-
11
-
-
2
-
2
-
-
-
2
-
-
-
-
-
3
-
2
-
-
-
-
-
3
8
-
-
-
-
-
2
-
-
-
-
-
11
-
-
2
-
2
-
-
-
2
-
-
-
-
2
2
-
-
-
734765
Chen
The Arabidopsis alkaline ceram ...
Arabidopsis thaliana, Arabidopsis thaliana Landsberg erecta
Nat. Commun.
6
6030
2015
-
-
1
-
1
-
-
-
2
-
-
-
-
5
-
-
-
-
-
4
-
-
2
1
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
4
-
-
2
1
1
-
-
-
-
-
-
-
-
2
2
-
-
-
734919
Wu
The Arabidopsis ceramidase AtA ...
Arabidopsis thaliana
Plant J.
81
767-780
2015
-
-
1
-
1
-
-
-
3
1
-
-
-
7
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
1
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1
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-
-
-
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3
1
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
4
4
-
-
-
733408
Ito
New insight into the structure ...
Aspergillus oryzae, Danio rerio, Dermatophilus congolensis, Dictyostelium discoideum, Drosophila melanogaster, Homo sapiens, Laodelphax striatella, Mus musculus, Mycobacterium tuberculosis, Oryza sativa, Pseudomonas aeruginosa, Rattus norvegicus, Tribolium castaneum, Triticum aestivum
Biochim. Biophys. Acta
1841
682-691
2014
2
-
14
1
2
-
-
-
14
16
-
1
-
18
-
7
-
14
-
21
-
-
2
1
-
-
-
-
12
-
-
-
-
-
-
2
-
14
-
1
2
-
-
-
-
-
14
16
-
1
-
-
7
-
-
21
-
-
2
1
-
-
-
-
12
-
-
-
1
32
32
1
-
-
735138
Oizumi
Pseudomonas-derived ceramidase ...
Pseudomonas aeruginosa
PLoS ONE
9
e89402
2014
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
733290
Ramachandra
Membrane topology of yeast alk ...
Saccharomyces cerevisiae
Biochem. J.
452
585-594
2013
-
-
1
-
19
-
1
-
4
-
-
2
-
3
-
-
-
-
-
-
-
-
4
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
19
-
-
1
-
-
6
-
-
2
-
-
-
-
-
-
-
-
4
-
2
-
-
-
2
-
-
-
-
3
5
-
-
-
733395
Morad
Novel off-target effect of tam ...
Homo sapiens
Biochim. Biophys. Acta
1831
1657-1664
2013
-
-
-
-
-
-
-
-
1
-
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1
-
1
-
-
-
-
-
5
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
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5
-
-
1
-
1
-
-
-
1
-
-
-
1
-
-
1
-
-
733498
Bhabak
Effective inhibition of acid a ...
Homo sapiens
Bioorg. Med. Chem.
21
874-882
2013
-
-
-
-
-
-
15
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
18
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
733654
Bhabak
Development of a novel FRET pr ...
Homo sapiens, Mus musculus
ChemBioChem
14
1049-1052
2013
-
-
-
-
-
-
-
2
-
-
-
2
-
2
-
-
-
-
-
3
-
-
6
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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2
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2
-
-
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-
-
3
-
-
6
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
733976
Zhou
Identification and biochemical ...
Laodelphax striatella
Insect Mol. Biol.
22
366-375
2013
1
-
1
-
-
-
-
-
-
2
1
-
-
3
-
-
1
-
-
-
-
-
9
1
1
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
2
1
-
-
-
-
1
-
-
-
-
9
1
1
-
-
-
1
-
-
-
1
1
1
1
-
-
733984
Chathoth
Purification and biochemical c ...
Camelus dromedarius
Int. J. Biochem. Mol. Biol.
4
54-66
2013
-
-
-
-
-
-
12
2
1
1
2
-
-
2
-
1
1
-
-
2
1
-
7
1
1
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
12
-
2
1
1
2
-
-
-
1
1
-
2
1
-
7
1
1
-
-
-
1
1
-
-
-
-
-
-
-
-
734369
Cheng
Radiation-induced acid ceramid ...
Homo sapiens
J. Clin. Invest.
123
4344-4358
2013
-
-
1
-
-
-
1
-
-
-
-
-
-
3
-
-
-
-
-
5
-
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1
-
-
-
-
-
1
-
-
-
-
-
-
-
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1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
5
-
-
1
-
-
-
-
-
1
-
-
-
1
1
1
1
-
-
734435
Camacho
Acid ceramidase as a therapeut ...
Homo sapiens
J. Lipid Res.
54
1207-1220
2013
-
-
1
-
-
-
8
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
-
1
-
-
-
-
2
2
-
-
-
734448
Pizzirani
Discovery of a new class of hi ...
Rattus norvegicus
J. Med. Chem.
56
3518-3530
2013
-
-
1
-
-
-
42
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
33
-
-
1
-
-
-
-
33
42
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
734696
Alves
Molecular basis of acid cerami ...
Homo sapiens
Mol. Genet. Metab.
109
276-281
2013
-
-
1
-
-
-
-
-
2
-
2
-
-
2
-
1
-
-
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
2
-
-
-
1
-
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
2
2
-
-
-
735103
Beckham
Acid ceramidase promotes nucle ...
Homo sapiens
PLoS ONE
8
e76593
2013
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
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2
2
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711949
Liu
Acid ceramidase upregulation i ...
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Expert Opin. Ther. Targets
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1
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1
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Characterization of a neutral ...
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1
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1
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2
1
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686962
Kim
Population genetic analysis of ...
Homo sapiens
Genetics
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687695
Shtraizent
Autoproteolytic cleavage and a ...
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J. Biol. Chem.
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688207
Sun
Upregulation of the human alka ...
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J. Invest. Dermatol.
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2008
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693589
Cho
Bioluminescent assay for sphin ...
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J. Microbiol.
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2008
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5
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693810
Ohlsson
Expression of intestinal and l ...
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J. Pediatr. Gastroenterol. Nutr.
47
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2008
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35
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9
35
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1
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1
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2
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695405
Zhu
Chronic activation of neutral ...
Rattus norvegicus
Acta Pharmacol. Sin.
29
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2008
1
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1
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1
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1
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1
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1
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-
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696396
Mao
Ceramidases: regulators of cel ...
Homo sapiens, Mus musculus
Biochim. Biophys. Acta
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2008
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2
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4
1
10
10
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12
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2
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2
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10
2
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5
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7
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6
3
10
10
-
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2
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2
-
-
10
2
-
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-
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5
-
-
-
-
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-
-
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700448
Acharya
Cell-nonautonomous function of ...
Drosophila melanogaster
Neuron
57
69-79
2008
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1
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1
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2
2
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3
-
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700748
Pata
Molecular cloning and characte ...
Oryza sativa
Plant J.
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1000-1009
2008
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1
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2
5
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7
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4
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1
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1
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1
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1
2
5
1
1
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4
-
1
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-
-
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1
-
-
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701233
Houben
Epidermal ceramidase activity ...
Mus musculus
Skin Pharmacol. Physiol.
21
111-118
2008
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-
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1
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1
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1
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2
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2
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1
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2
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2
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678434
Duan
Effects of bile diversion in r ...
Rattus norvegicus
Biochim. Biophys. Acta
1771
196-201
2007
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1
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3
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1
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1
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3
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1
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-
-
-
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-
679649
Duan
-
Sphingomyelinase and ceramidas ...
Homo sapiens
Eur. J. Lipid Sci. Technol.
109
987-993
2007
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2
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1
1
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1
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1
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1
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1
1
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1
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-
-
-
-
-
-
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1
-
-
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680936
Okino
Ceramidase enhances phospholip ...
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282
6021-6030
2007
1
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1
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7
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1
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6
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1
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1
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1
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1
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1
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1
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4
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1
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6
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1
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1
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685419
Ohlsson
Purification and characterizat ...
Homo sapiens
Biochimie
89
950-960
2007
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9
1
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1
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4
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1
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3
1
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4
1
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2
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9
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1
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1
1
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1
1
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3
1
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4
1
-
-
-
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2
-
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-
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685909
Saad
The functional effects of acid ...
Homo sapiens
Cancer Biol. Ther.
6
1455-1460
2007
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2
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2
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-
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686632
Eliyahu
Acid ceramidase is a novel fac ...
Mus musculus
FASEB J.
21
1403-1409
2007
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1
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-
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1
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-
-
-
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688222
Wu
Large-scale purification and c ...
Pseudomonas sp.
J. Lipid Res.
48
600-608
2007
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1
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1
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1
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1
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1
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1
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1
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-
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667523
Galadari
Identification of a novel amid ...
Homo sapiens, no activity in Saccharomyces cerevisiae, Rattus norvegicus
Biochem. J.
393
687-695
2006
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5
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1
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8
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14
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2
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8
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1
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2
1
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5
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2
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2
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668541
Xu
Golgi alkaline ceramidase regu ...
Homo sapiens
FASEB J.
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2006
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3
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1
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1
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1
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3
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3
1
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5
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1
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-
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1
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668638
Elojeimy
New insights on the use of des ...
Homo sapiens
FEBS Lett.
580
4751-4756
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1
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1
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1
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4
1
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-
-
-
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669485
Zeidan
Acid ceramidase but not acid s ...
Mus musculus
J. Biol. Chem.
281
24695-24703
2006
1
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2
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2
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1
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1
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1
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1
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1
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1
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1
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2
-
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2
-
1
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1
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669517
Kono
Neutral ceramidase encoded by ...
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281
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1
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1
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1
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1
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11
1
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669761
Houben
Differentiation-associated exp ...
Homo sapiens
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1
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1
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1
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2
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685316
Park
Acid ceramidase and human dise ...
Homo sapiens
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1
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664859
Jensen
Acid and neutral sphingomyelin ...
Mus musculus
Exp. Dermatol.
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609-618
2005
1
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1
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1
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2
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1
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1
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667409
Hwang
Subcellular localization of hu ...
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1
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669340
Chavez
Acid ceramidase overexpression ...
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1
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Tani
Involvement of neutral ceramid ...
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1
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1
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2
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1
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2
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