Application | Comment | Organism |
---|---|---|
medicine | in human prostate tissues, acid ceramidase and cathepsin B overexpression are strongly associated and may relate to poor outcome | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
13000 | - |
x * 13000, SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
DU-145 cell | - |
Homo sapiens | - |
DuPro cell | - |
Homo sapiens | - |
PC-3 cell | - |
Homo sapiens | - |
PPC-1 cell | - |
Homo sapiens | - |
prostate gland | - |
Homo sapiens | - |
Subunits | Comment | Organism |
---|---|---|
? | x * 13000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
acid ceramidase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | acid ceramidase is overexpressed in most prostate tumors | up |
General Information | Comment | Organism |
---|---|---|
physiological function | acid ceramidase, through generation of sphingosine-1-phosphate, promotes an invasive phenotype in prostate cancer and promotes Ets1 nuclear expression and binding to the promoter region of matrix-degrading protease cathepsin B. Acid ceramidase overexpression promotes pericellular localization of cathepsin B and its translocation to the outer leaflet of the cell membrane | Homo sapiens |