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Literature summary for 3.5.1.23 extracted from

  • Park, J.; Yoon, S.
    Ceramide, a crucial functional lipid, and its metabolic regulation by acid ceramidase (2010), Food Sci. Biotechnol., 19, 859-864.
No PubMed abstract available
Search for more literature for 3.5.1.23

Application

Application Comment Organism
medicine inhibition of acid ceramidase is useful in cancer treatment Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in CHO cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(1R,2R)-2-N-myristoylamino-1-(4-nitrophenyl)-1,3-propandiol
-
 Homo sapiens
(1R,2R)-2-N-myristoylamino-1-(4-nitrophenyl)-1,3-propandiol
-
 Mus musculus
(1S,2R)-2-N-myristoylamino-1-phenyl-1-propanol
-
 Homo sapiens
(1S,2R)-2-N-myristoylamino-1-phenyl-1-propanol
-
 Mus musculus
1R,2R-(2-N-myristoylamino-1-(4-nitrophenyl)-1,3-dihydroxypropane)
-
 Homo sapiens
1R,2R-(2-N-myristoylamino-1-(4-nitrophenyl)-1,3-dihydroxypropane)
-
 Mus musculus
1S,2S-(2-N-myristoylamino-1-(4-nitrophenyl)-1,3-dihydroxypropane)
-
 Homo sapiens
1S,2S-(2-N-myristoylamino-1-(4-nitrophenyl)-1,3-dihydroxypropane)
-
 Mus musculus
N-oleoylethanolamine
-
 Homo sapiens
N-oleoylethanolamine
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Mus musculus 5764
-
lysosome
-
 Homo sapiens 5764
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
13000
-
 x * 40000 + 1 * 13000 Homo sapiens
40000
-
 x * 40000 + 1 * 13000 Homo sapiens
53000
-
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ceramide + H2O Mus musculus
-
 sphingosine + fatty acid
-
 r
ceramide + H2O Homo sapiens
-
 sphingosine + fatty acid
-
 r
N-lauroylsphingosine + H2O Homo sapiens
-
 laurate + sphingosine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Mus musculus
glycoprotein
-
 Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
concanavalin A column chromatography, Blue Sepharose column chromatography, and Superose 12 gel filtration Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
oocyte acid ceramidase protein is observed in unfertilized eggs Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ceramide + H2O
-
 Mus musculus sphingosine + fatty acid
-
 r
ceramide + H2O
-
 Homo sapiens sphingosine + fatty acid
-
 r
N-lauroylsphingosine + H2O
-
 Homo sapiens laurate + sphingosine
-
 ?

Subunits

Subunits Comment Organism
heterodimer x * 40000 + 1 * 13000 Homo sapiens

Synonyms

Synonyms Comment Organism
acid ceramidase
-
 Mus musculus
acid ceramidase
-
 Homo sapiens
N-acylsphingosine deacylase
-
 Mus musculus
N-acylsphingosine deacylase
-
 Homo sapiens

Expression

Organism Comment Expression
Mus musculus acid ceramidase protein and mRNA are decreased during egg aging down
Homo sapiens significantly decreased ceramide levels are observed in human colon cancers, gliomas, ovarian cancers, thyroid and gastrointestinal cancers down

General Information

General Information Comment Organism
malfunction inhibition of acid ceramidase activity stimulates apoptotic cell death. Point mutations in the acid ceramidase gene cause rare autosomal recessive Farber disease. Homozygous acid ceramidase-deficient mice are embryonic lethal Mus musculus
physiological function the enzyme determines cell fate, namely, death or survival, by controlling the balance between the intracellular levels of ceramide and sphingosine 1-phosphate. Acid ceramidase plays an important role in tumorigenesis and in prolonging the survival of cells Homo sapiens