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Literature summary for 3.5.1.108 extracted from

  • Coggins, B.E.; Li, X.; McClerren, A.L.; Hindsgaul, O.; Raetz, C.R.; Zhou, P.
    Structure of the LpxC deacetylase with a bound substrate-analog inhibitor (2003), Nat. Struct. Biol., 10, 645-651.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.108

Protein Variants

Protein Variants Comment Organism
K227E completely inactive mutant enzyme Aquifex aeolicus

Inhibitors

Inhibitors Comment Organism Structure
1,5-anhydro-2-C-(carboxymethyl-N-hydroxyamide)-2-deoxy-3-O-myristoyl-D-glucitol the solution structure of LpxC in complex with the substrate-analog inhibitor 1,5-anhydro-2-C-(carboxymethyl-N-hydroxyamide)-2-deoxy-3-O-myristoyl-D-glucitol, reveals a novel alpha/beta fold, a unique zinc-binding motif and a hydrophobic passage that captures the acyl chain of the inhibitor Aquifex aeolicus

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ the solution structure of LpxC in complex with the substrate-analog inhibitor 1,5-anhydro-2-C-(carboxymethyl-N-hydroxyamide)-2-deoxy-3-O-myristoyl-D-glucitol, reveals a novel alpha/beta fold, a unique zinc-binding motif and a hydrophobic passage that captures the acyl chain of the inhibitor Aquifex aeolicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O Aquifex aeolicus LpxC catalyzes the first committed step in the biosynthesis of lipid A, the hydrophobic anchor of lipopolysaccharide (LPS) that constitutes the outermost monolayer of Gram-negative bacteria. As LpxC is crucial for the survival of Gram-negative organisms and has no sequence homology to known mammalian deacetylases or amidases UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate
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Organism

Organism UniProt Comment Textmining
Aquifex aeolicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O
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 Aquifex aeolicus UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate
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UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O LpxC catalyzes the first committed step in the biosynthesis of lipid A, the hydrophobic anchor of lipopolysaccharide (LPS) that constitutes the outermost monolayer of Gram-negative bacteria. As LpxC is crucial for the survival of Gram-negative organisms and has no sequence homology to known mammalian deacetylases or amidases Aquifex aeolicus UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate
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 ?