Application | Comment | Organism |
---|---|---|
medicine | the anticancer activity of purified asparaginase is comparable or higher than that of commercial Escherichia coli asparaginase. The purified enzyme induces apoptotic cell death in dose-dependent manner, probybly via activation of anintrinsic apoptotic pathway. The purified enzyme is nontoxic for human noncancerous FR-2 cells and human blood lymphocytes | Pseudomonas otitidis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | 150 mM, about 75% of initial activity | Pseudomonas otitidis | |
Cd2+ | 10 mM, loss of activity | Pseudomonas otitidis | |
EDTA | 5 mM, about 85% residual activity | Pseudomonas otitidis | |
Fe3+ | 100 mM, about 55% of initial activity | Pseudomonas otitidis | |
Hg2+ | 100 mM, loss of activity | Pseudomonas otitidis | |
Mg2+ | 40 mM, about 30% of initial activity | Pseudomonas otitidis | |
Mn2+ | 100 mM, about 75% of initial activity | Pseudomonas otitidis | |
Ni2+ | 10 mM, loss of activity | Pseudomonas otitidis | |
SDS | 2 mM, about 55% residual activity | Pseudomonas otitidis | |
Thiourea | 1 mM, about 85% residual activtiy | Pseudomonas otitidis | |
Zn2+ | 100 mM, about 60% of initial activity | Pseudomonas otitidis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
K+ | 150 mM, about 130% of initial activity | Pseudomonas otitidis | |
Na+ | 50 mM, about 115% of initial activity | Pseudomonas otitidis |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
205000 | - |
PAGE | Pseudomonas otitidis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas otitidis | A0A1I0U0N3 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
107.84 | - |
pH 8.6, 37°C | Pseudomonas otitidis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-asparagine + H2O | - |
Pseudomonas otitidis | L-aspartate + NH3 | - |
? | |
additional information | poor or no substrates: D-asparagine, L-glutamine, D-glutamine, L-histidine, L-ornithine, Boc-L-asapragine, N-alpha-acetyl-L-asparagine, urea, acrylamide | Pseudomonas otitidis | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
hexamer | 6 * 34000, SDS-PAGE | Pseudomonas otitidis |
Synonyms | Comment | Organism |
---|---|---|
SAMN05216263_10744 | - |
Pseudomonas otitidis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
40 | - |
- |
Pseudomonas otitidis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
- |
Pseudomonas otitidis |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Pseudomonas otitidis | isoelectric focussing | - |
5.5 |