Activating Compound | Comment | Organism | Structure |
---|---|---|---|
KYFTGSKLWRSYYA | peptidic activator, based on the Blm10 activator of 20S proteasome. At 10 microM concentration, chymotrypsin-like and peptidylglutamyl peptide hydrolyzing activities increase around three times whereas trypsin-like activity increases around 7fold | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
in complex with peptide KYFTGSKLWRSYYA, to 3 A resolution | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Boc-Leu-Leu-Glu-4-methylcoumarin-7-amide + H2O | - |
Homo sapiens | Boc-Leu-Leu-Glu + 7-amino-4-methylcoumarin | - |
? | |
succinyl-Leu-Leu-Val-Tyr-4-methylcoumarin-7-amide + H2O | - |
Homo sapiens | succinyl-Leu-Leu-Val-Tyr + 7-amino-4-methylcoumarin | - |
? | |
tert-butyloxycarbonyl-Leu-Arg-Arg-4-methylcoumarin-7-amide | - |
Homo sapiens | ? | - |
? |