Literature summary for 3.4.25.1 extracted from

Zhang, Q.; Ji, S.; Busayavalasa, K.; Shao, J.; Yu, C.
Meiosis I progression in spermatogenesis requires a type of testis-specific 20S core proteasome (2019), Nat. Commun., 10, 31358751 .

No PubMed abstract available

Search for more literature for 3.4.25.1

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q9CWH6	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
spermatocyte	subunit PSMA8-associated proteasomes are essential for the degradation of meiotic proteins and the progression of meiosis I during spermatogenesis	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
proteasome subunit alpha-type 7-like	-	Mus musculus
Psma8	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	subunit PSMA8 is expressed in spermatocytes from the pachytene stage, and assembles a type of testis-specific core proteasome. Deletion of PSMA8 decreases the abundance of proteasome in testes. Meiotic proteins that are normally degraded at late prophase I, such as RAD51 and RPA1, remain stable in PSMA8-deleted spermatocytes. PSMA8-null spermatocytes exhibit delayed M-phase entry and are finally arrested at this stage, resulting in male infertility	Mus musculus

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Release 2023.1 (January 2023)