Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AG1296 | a platelet-derived growth factor receptor inhibitor, shows several physiological effects, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular matrix | - |
Mus musculus | 31012 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | required | Mus musculus | |
Zn2+ | required | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gelatin + H2O | Mus musculus | - |
? | - |
? | |
additional information | Mus musculus | MMP-13 degrades intact collagen and participates in situations where rapid and effective remodeling of collagenous extracellular matrix is required | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MC3T3-E1 cell | - |
Mus musculus | - |
osteoblast | primary | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gelatin + H2O | - |
Mus musculus | ? | - |
? | |
additional information | MMP-13 degrades intact collagen and participates in situations where rapid and effective remodeling of collagenous extracellular matrix is required | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
collagenase 3 | - |
Mus musculus |
MMP-13 | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at room temperature | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | mechanical strain induction of MMP-13 by high mechanical forces, with receptor of platelet-derived growth factor receptor alpha, PDGFR-alpha, as a potential mechanoreceptor in the MMP-13 induction, inhibited by platelet-derived growth factor receptor inhibitor AG1296, overview. The receptor performs autophosphorylation under mechanical stress | up |
General Information | Comment | Organism |
---|---|---|
physiological function | MMP-13 participate in the bone-remodeling mechanism involving the platelet-derived growth factor receptor | Mus musculus |