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Literature summary for 3.4.24.B4 extracted from

  • Varga, F.; Rumpler, M.; Spitzer, S.; Karlic, H.; Klaushofer, K.
    Osteocalcin attenuates T3- and increases vitamin D3-induced expression of MMP-13 in mouse osteoblasts (2009), Endocr. J., 56, 441-450.
    View publication on PubMed
Search for more literature for 3.4.24.B4

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular matrix
-
 Mus musculus 31012
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Type I collagen + H2O Mus musculus
-
 ?
-
 ?
type II collagen + H2O Mus musculus
-
 ?
-
 ?
type III collagen + H2O Mus musculus
-
 ?
-
 ?
type X collagen + H2O Mus musculus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone
-
 Mus musculus
-
cartilage
-
 Mus musculus
-
MC3T3-E1 cell
-
 Mus musculus
-
osteoblast
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Type I collagen + H2O
-
 Mus musculus ?
-
 ?
type II collagen + H2O
-
 Mus musculus ?
-
 ?
type III collagen + H2O
-
 Mus musculus ?
-
 ?
type X collagen + H2O
-
 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
collagenase-3
-
 Mus musculus
MMP-13
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus 1,25-dihydroxy vitamin D3, 1,25D3, and T3 hormones induce MMP-13 expression in osteoblasts and are important for enzyme regulation in bone. The activation of MMP-13 expression by T3 is in a competitive balance with the regulation of osteocalcin expression, overview. PKA inhibitor HA1004 stimulates 1,25D3 activation of MMP-13 expression and reduces the stimulation by T3 up

General Information

General Information Comment Organism
metabolism the activation of MMP-13 expression by T3 is in a competitive balance with the regulation of osteocalcin expression, overview Mus musculus
physiological function MMP-13 is a matrix metalloproteinase that is important for bone development and remodelling Mus musculus