Literature summary for 3.4.24.B12 extracted from

Durigova, M.; Troeberg, L.; Nagase, H.; Roughley, P.J.; Mort, J.S.
Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilage (2011), Eur. Cell Mater., 21, 31-45.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
aggrecan + H2O	ADAMTS5 is the most active aggrecanase compared to ADAMTS4 and is responsible for the generation of an oncostatin M-specific degradation pattern in the CS-2 region. ADAMTS5 has the ability to cleave at the oncostatin M-specific site adjacent to the aggrecan G3 region (Glu373-Ala374 bond). Truncation of the C-terminal TS domain or Sp domain does not affect the ability of the enzyme to cleave at this site	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
ADAMTS5	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	interleukin-1beta+OSM and tumor necrosis factor alpha+ OSM treatments induces a 17fold and 13fold increase in ADAMTS5 gene expression. Relatively little modulation in ADAMTS5 expression is observed in the presence of interleukin-1beta, tumor necrosis factor alpha or OSM alone	up

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Release 2023.1 (January 2023)