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Literature summary for 3.4.24.B12 extracted from

  • Mosyak, L.; Georgiadis, K.; Shane, T.; Svenson, K.; Hebert, T.; McDonagh, T.; Mackie, S.; Olland, S.; Lin, L.; Zhong, X.; Kriz, R.; Reifenberg, E.L.; Collins-Racie, L.A.; Corcoran, C.; Freeman, B.; Zollner, R.; Marvell, T.; Vera, M.; Sum, P.E.; Lavallie, E.R.; Stahl, M.; Somers, W.
    Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5 (2008), Protein Sci., 17, 16-21.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.B12

Cloned(Commentary)

Cloned (Comment) Organism
expressed in CHO cells Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with batimastat, vapour diffusion method at 18°C using 10% PEG 8K, 0.2 M ammonium sulfate, and 0.1M MES (pH 6.5) as a precipitate Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
batimastat
-
 Homo sapiens
N-[(1R)-1-(dihydroxymethyl)-2-methylpropyl]-4'-{[4-(2-methylpropanoyl)phenoxy]methyl}biphenyl-4-sulfonamide
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Strep-Tactin affinity chromatography and Superdex-200 gel filtration Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Abz-TEGEARGSVI-Dap(2,4-dinitrophenyl)-KK + H2O
-
 Homo sapiens ?
-
 ?
aggrecan + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
a disintegrin and metalloproteinase with thrombospondin motifs 5
-
 Homo sapiens
ADAMTS5
-
 Homo sapiens
aggrecanase-2
-
 Homo sapiens