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Literature summary for 3.4.24.87 extracted from
- ADAMTS13, von Willebrand factor specific cleaving protease (2011), Med. Sci. (Paris), 27, 1097-1105.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| von Willebrand factor + H2O | Homo sapiens | - |
? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| von Willebrand factor + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| a disintegrin and metalloprotease with thrombospondin type 1 repeats 13 | - |
Homo sapiens |
| ADAMTS13 | - |
Homo sapiens |
| von Willebrand factor specific cleaving protease | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | a severe functional deficiency of ADAMTS13 (activity lower than 10%) is associated with thrombotic thrombocytopenic purpura | Homo sapiens |
| physiological function | multimeric von Willebrand factor is the mediator of both platelet adhesion to the sub-endothelium and platelet aggregation within the microvessels at high shear rates of blood flow. ADAMTS13 regulates von Willebrand factor adhesive capacity by reducing the size of von Willebrand factor multimers | Homo sapiens |
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