Organism | UniProt | Comment | Textmining |
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Bacillus anthracis | - |
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General Information | Comment | Organism |
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physiological function | secreted type-IIA phospholipase A2sPLA2-IIA expression is induced via a sequential MAPK-NF-kappaB activation and anthrax lethal toxin inhibits this expression likely by interfering with the transactivation of NF-kappaB in the nucleus. Anthrax lethal toxin inhibits IL-1b-induced p38 phosphorylation as well as sPLA2-IIA promoter activity in CHO cells. Inhibition of sPLA2-IIA promoter activity is mimicked by co-transfection with dominant negative construct of p38 and reversed by the active form of p38-MAPK. Both anthrax lethal toxin and the dominant negative construct of p38 decrease IL-1b-induced NF-kappaB luciferase activity. Neither anthrax lethal toxin nor specific p-38 inhibitor interfere with LPS-induced IkappaBalpha degradation or NF-kappaB nuclear translocation in guinea pig alveolar macrophages. Subcutaneous administration of anthrax lethal toxin to guinea pig before LPS challenge reduces sPLA2-IIA levels in broncho-alveolar lavages and ear | Bacillus anthracis |