Literature summary for 3.4.24.83 extracted from

Reig, N.; Jiang, A.; Couture, R.; Sutterwala, F.S.; Ogura, Y.; Flavell, R.A.; Mellman, I.; van der Goot, F.G.
Maturation modulates caspase-1-independent responses of dendritic cells to Anthrax lethal toxin (2008), Cell. Microbiol., 10, 1190-1207.

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Application

Application	Comment	Organism
molecular biology	the cellular damage inflicted by anthrax lethal toxin depends not only on the innate responses but also on the maturation stage of the cell, which modulates the more general caspase-1-independent responses	Bacillus anthracis

Protein Variants

Protein Variants	Comment	Organism
additional information	the responses of various murine dendritic cells to anthrax lethal toxin is investigated: Using a variety of knockout mice, it is shown that depending on the mouse strain, death of bone marrow-derived dendritic cells and macrophages is mediated either by a fast Nalp1b, a member of the NOD-like receptor family, and caspase-1-dependent, or by a slow caspase-1-independent pathway that is triggered by the impairment of MEK1/2 pathways. Caspase-1-independent death is observed in cells of different genetic backgrounds and interestingly occurs only in immature dendritic cells. Maturation, triggered by different types of stimuli, leads to full protection of dendritic cells	Bacillus anthracis

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Bacillus anthracis	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
anthrax lethal toxin	-	Bacillus anthracis

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Release 2023.1 (January 2023)