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Literature summary for 3.4.24.82 extracted from

  • Fontanil, T.; Alvarez-Teijeiro, S.; Villaronga, M.A.; Mohamedi, Y.; Solares, L.; Moncada-Pazos, A.; Vega, J.A.; Garcia-Suarez, O.; Perez-Basterrechea, M.; Garcia-Pedrero, J.M.; Obaya, A.J.; Cal, S.
    Cleavage of fibulin-2 by the aggrecanases ADAMTS-4 and ADAMTS-5 contributes to the tumorigenic potential of breast cancer cells (2017), Oncotarget, 8, 13716-13729 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
aggrecan + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O75173
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
SK-BR-3 cell
-
 Homo sapiens
-
T-47D cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
aggrecan + H2O
-
 Homo sapiens ?
-
 ?
fibulin-2 + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ADAMTS-4
-
 Homo sapiens
aggrecanase
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function fibulin-2 degradation by the enzyme is associated to an enhancement of the invasive potential of T-47D, MCF-7 and SK-BR-3 breast cancer cells Homo sapiens