Cloned (Comment) | Organism |
---|---|
gene MMP14, quantitative RT-PCR enzyme expression analysis | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | a zinc-dependent endopeptidase | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P50281 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
placenta | - |
Homo sapiens | - |
trophoblast | primary human trophoblasts from 50 first trimester placentas (gestational week 7-12), high MMP115 expression | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
matrix metalloproteinase 14 | - |
Homo sapiens |
MMP14 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | endothelin-1 (ET-1) downregulates matrix metalloproteinase 14 expression in human first trimester trophoblasts via endothelin receptor type B (ETRB). ET-1 downregulates MMP14 mRNA and protein levels. TNF-alpha enhances ET-1-mediated MMP14 downregulation in primary trophoblasts | down |
General Information | Comment | Organism |
---|---|---|
metabolism | MMP14 and MMP15 are involved in trophoblast invasion | Homo sapiens |