Literature summary for 3.4.24.74 extracted from

Yoon, Y.M.; Lee, J.Y.; Yoo, D.; Sim, Y.S.; Kim, Y.J.; Oh, Y.K.; Kang, J.S.; Kim, S.; Kim, J.S.; Kim, J.M.
Bacteroides fragilis enterotoxin induces human beta-defensin-2 expression in intestinal epithelial cells via a mitogen-activated protein kinase/I kappaB kinase/NF-kappaB-dependent pathway (2010), Infect. Immun., 78, 2024-2033.

Search for more literature for 3.4.24.74

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	the enzyme is secreted	Bacteroides fragilis	-	-

Organism

Organism	UniProt	Comment	Textmining
Bacteroides fragilis	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
native enzyme from culture supernatant	Bacteroides fragilis

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
BFT	-	Bacteroides fragilis

General Information

General Information	Comment	Organism
physiological function	role of BFT in human host beta-defensin 2 induction from intestinal epithelial cells, HT-29 and Caco-2, requiring the presence of NF-kappaB binding sites. Also binding of NF-kappaB to the hBD-2 promoter is required for the induction of the hBD-2 gene in BFT-stimulated intestinal epithelial cells, while AP-1 is not involved, regulation, overview. Heat-labile enterotoxin BFT plays an essential role in host mucosal inflammation	Bacteroides fragilis

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)