Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | MMP-1 is secreted by skin fibroblasts | Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Homo sapiens | - |
skin | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
matrix metalloproteinase-1 | - |
Homo sapiens |
MMP-1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | UVA and UVB irradiation of dermal fibroblasts in vitro or human skin in vivo induces MMP-1 expression. MMP-1 expression and secretion induced by UV-B irradiation is inhibited by trans-zeatin, a cytokinin from Zea mays, and by PD98059, an ERK inhibitor, by SP600125, a JNK inhibitor and by SB203580, a p38 MAPK inhibitor. trans-Zeatin also inhibits UVB-induced ERK, JNK, p38 MAPK and c-Jun phosphorylation | up |
General Information | Comment | Organism |
---|---|---|
physiological function | MMP-1 is implicated in the degradation of human skin matrix proteins such as collagen and other components of extracellular matrix | Homo sapiens |