Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ala-Ser-Gln-Phe-Glu-Thr-Ser | synthetic peptide containing cleavage site of synaptobrevin, inhibits toxin action on buccal ganglion of Aplysia californica | Clostridium tetani | |
captopril | - |
Clostridium tetani | |
EDTA | - |
Clostridium tetani | |
Gln-Phe-Glu-Thr | synthetic peptide containing cleavage site of synaptobrevin, inhibits toxin action on buccal ganglion of Aplysia californica | Clostridium tetani |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zinc | zinc-dependent endoproteinase | Clostridium tetani |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
synaptobrevin + H2O | Clostridium tetani | enzyme disables neuroexocytosis apparatus, acts at spinal inhibitory interneurons, blocking release of various neurotransmitters to produce spastic paralysis, clostridial neurotoxins are described as the most toxic substances known | ? | - |
? | |
synaptobrevin + H2O | Clostridium tetani | neurotoxin blocks neurotransmitter release in Aplysia neurons | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Clostridium tetani | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | catalytic activity requires reduction of the single interchain disulfide bond of the neurotoxin | Clostridium tetani | ? | - |
? | |
additional information | no substrates are rat or chicken | Clostridium tetani | ? | - |
? | |
Synaptobrevin + H2O | i.e. VAMP, neuronal vesicle-associated membrane protein, MW 19000, with 2 isoforms in human, chicken, in rat brain: synaptobrevin/VAMP-1 and synaptobrevin/VAMP-2, cleaves at Gln76-Phe77, the same site as botulin neurotoxin B | Clostridium tetani | Hydrolyzed synaptobrevin | - |
? | |
synaptobrevin + H2O | enzyme disables neuroexocytosis apparatus, acts at spinal inhibitory interneurons, blocking release of various neurotransmitters to produce spastic paralysis, clostridial neurotoxins are described as the most toxic substances known | Clostridium tetani | ? | - |
? | |
synaptobrevin + H2O | neurotoxin blocks neurotransmitter release in Aplysia neurons | Clostridium tetani | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Clostridium tetani |