Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | role of the P'3 position in inhibitor selectivity, overview, interaction of compound 1 with the catalytic domain of MMP12, molecular modeling, overview | Homo sapiens | |
N-(3-[(4-bromophenyl)(hydroxy)phosphoryl]-2-[3-[4-(dimethylamino)phenyl]isoxazol-5-yl]propanoyl)-L-alpha-glutamyl-L-alpha-glutamine | - |
Homo sapiens | |
N-[3-[(4-bromophenyl)(hydroxy)phosphoryl]-2-[3-(3'-chlorobiphenyl-4-yl)isoxazol-5-yl]propanoyl]-L-alpha-glutamyl-L-alpha-glutamine | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Homo sapiens | |
Zn2+ | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 + H2O | - |
Homo sapiens | Mca-Pro-Leu-Gly + Leu-Dpa-Ala-Arg-NH2 | - |
? | |
Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dpa-NH2 + H2O | selective cleavage, the Glu-Glu motif interacts with the S'2 and S'3 subsites of MMP-12 | Homo sapiens | Mca-Pro-Leu-Gly + Leu-Glu-Glu-Ala-Dpa-NH2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Matrix metalloproteinase-12 | - |
Homo sapiens |
MMP-12 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.8 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00000019 | - |
N-[3-[(4-bromophenyl)(hydroxy)phosphoryl]-2-[3-(3'-chlorobiphenyl-4-yl)isoxazol-5-yl]propanoyl]-L-alpha-glutamyl-L-alpha-glutamine | - |
Homo sapiens | |
0.0000044 | - |
N-(3-[(4-bromophenyl)(hydroxy)phosphoryl]-2-[3-[4-(dimethylamino)phenyl]isoxazol-5-yl]propanoyl)-L-alpha-glutamyl-L-alpha-glutamine | - |
Homo sapiens |