Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.61 extracted from

  • Kanda, K.; Sakamoto, J.; Matsumoto, Y.; Ikuta, K.; Goto, N.; Morita, Y.; Ohno, M.; Nishi, K.; Eto, K.; Kimura, Y.; Nakanishi, Y.; Ikegami, K.; Yoshikawa, T.; Fukuda, A.; Kawada, K.; Sakai, Y.; Ito, A.; Yoshida, M.; Kimura, T.; Chiba, T.; Nishi, E.; Seno, H.
    Nardilysin controls intestinal tumorigenesis through HDAC1/p53-dependent transcriptional regulation (2018), JCI Insight, 3, 91316 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.61

Organism

Organism UniProt Comment Textmining
Homo sapiens O43847
-
-
Mus musculus Q8BHG1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colorectal cancer cell line highly expressed in human colorectal cancers Homo sapiens
-

Synonyms

Synonyms Comment Organism
N-Arginine dibasic convertase
-
 Homo sapiens
N-Arginine dibasic convertase
-
 Mus musculus
NRDc
-
 Homo sapiens
NRDc
-
 Mus musculus

General Information

General Information Comment Organism
malfunction deletion of the Nrdc gene in ApcMin mice crucially suppresses intestinal tumor development. In ApcMin mice, epithelial cell-specific deletion of Nrdc recapitulates the tumor suppression observed in Nrdc-null mice Mus musculus
physiological function epithelial cell-specific overexpression of Nrdc significantly enhances tumor formation in ApcMin mice Mus musculus
physiological function the enzyme controls intestinal tumorigenesis through HDAC1/p53-dependent transcriptional regulation Homo sapiens