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Literature summary for 3.4.24.61 extracted from

  • Borrmann, C.; Stricker, R.; Reiser, G.
    Tubulin potentiates the interaction of the metalloendopeptidase nardilysin with the neuronal scaffold protein p42IP4/centaurin-alpha1 (ADAP1) (2011), Cell Tissue Res., 346, 89-98.
    View publication on PubMed
Search for more literature for 3.4.24.61

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Protein Variants

Protein Variants Comment Organism
C948A the mutation of a highly conserved cysteine residue in NRD to Ala abolishes the potentiation by tubulin Homo sapiens
additional information NRD lacking the characteristic acidic domain is able to bind p42IP4 but addition of tubulin does not significantly potentiate the binding of this deletion mutant to p42IP4. A function-abolishing mutation of the Zn2+-binding motif of NRD does not affect the potentiation by tubulin Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol p42IP4 (centaurin-alpha), nardilysin and tubulin are found in the cytosol and at the plasma membrane of SH-SY5Y neuroblastoma cells Homo sapiens 5829
-
plasma membrane p42IP4 (centaurin-alpha), nardilysin and tubulin are found in the cytosol and at the plasma membrane of SH-SY5Y neuroblastoma cells Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens tubulin enhances the binding of NRD to functionally p42IP4 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell mRNA isolated from Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information tubulin enhances the binding of NRD to functionally p42IP4 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
nardilysin
-
 Homo sapiens