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Literature summary for 3.4.24.35 extracted from

  • Yuan, G.; Chen, L.; Feng, J.; Yang, G.; Ni, Q.; Xu, X.; Wan, C.; Lindsey, M.; Donly, K.J.; MacDougall, M.; Chen, Z.; Chen, S.
    Dentin sialoprotein is a novel substrate of matrix metalloproteinase 9 in vitro and in vivo (2017), Sci. Rep., 7, 42449 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dentin sialoprotein + H2O Mus musculus the enzyme highly efficiently cleaves dentin sialoprotein into distinct fragments in vitro, and the deletion of Mmp9 causes improper processing of dentin sialoprotein in natural teeth ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P41245
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-

Source Tissue

Source Tissue Comment Organism Textmining
tooth MMP9 is expressed in teeth from early embryonic to adult stage Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dentin sialoprotein + H2O the enzyme highly efficiently cleaves dentin sialoprotein into distinct fragments in vitro, and the deletion of Mmp9 causes improper processing of dentin sialoprotein in natural teeth Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
Matrix metalloproteinase 9
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 Mus musculus
MMP9
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 Mus musculus

General Information

General Information Comment Organism
malfunction the enzyme is important for tooth development. Teeth of Mmp9-/- mice displayed a phenotype similar to dentinogenesis imperfecta, including decreased dentin mineral density, abnormal dentin architecture, widened predentin and irregular predentin-dentin boundary Mus musculus