Cloned (Comment) | Organism |
---|---|
gene MMP9, quantitative RT-PCR enzyme expression analysis | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha-linolenic acid | - |
Homo sapiens | |
docosahexaenoic acid | - |
Homo sapiens | |
gamma-linolenic acid | - |
Homo sapiens | |
linoleic acid | - |
Homo sapiens | |
additional information | omega-3 and omega-6 fatty acids act as inhibitors of matrix metalloproteinase-9 activity. Omega-3 and omega-6 fatty acids contribute to the structure and function of the phospholipid bilayers in cellular membranes and act as precursors of lipid-mediated signaling molecules | Homo sapiens | |
oleic acid | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | the enzyme is secreted | Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | required | Homo sapiens | |
Zn2+ | a zinc-dependent metalloprotease | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P14780 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | activation of pro-MMP-2 with 1 mM APMA (p-aminophenylmercuric acetate) overnight at 37°C, in buffer containing 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM CaCl2, and 0.05% Brij L23 | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Mca-KPLGL-(Dpa)-AR-NH2 + H2O | - |
Homo sapiens | ? | - |
? | |
additional information | enzyme activity is determined using human teeth as substrate | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Matrix metalloproteinase 9 | - |
Homo sapiens |
MMP-9 | - |
Homo sapiens |
progelatinase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
20 | 22 | assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |