Cloned (Comment) | Organism |
---|---|
gene MMP9, quantitative RT-PCR enzyme expression analysis | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | the enzyme is secreted | Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | a zinc-dependent metalloprotease | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gelatin + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P14780 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
sputum | Mycobacterium tuberculosis stimulates matrix metalloproteinases secretion in the host. Analysis of the patterns of matrix metalloproteinase 9 (MMP-9) and 2 (MMP-2) isoforms in sputum samples, overview. Variations in MMP-9 isoforms are observed, which coincide with the progression of tuberculosis infection | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gelatin + H2O | - |
Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | four isoforms of MMP-9 have been reported: the first is a latent form, a zymogen of 92 kDa. The second is obtained by cutting the prodomain of the latent form, resulting in a product of 82 kDa, which produces the active form of the enzyme. The third isoform is a heterodimer that originates from the binding of MMP-9 with the inhibitor TIMP-1, generating a product of 220 kDa. Finally, the fourth isoform corresponds to a 125 kDa heterodimer, made up of MMP-9 associated with lipocalin. Analysis of MMP-9 isoforms identification and determination of activities | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
Matrix metalloproteinase 9 | - |
Homo sapiens |
MMP-9 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | Mycobacterium tuberculosis stimulates matrix metalloproteinases secretion in the host | up |
General Information | Comment | Organism |
---|---|---|
additional information | four isoforms of MMP-9 have been reported: the first is a latent form, a zymogen of 92 kDa. The second is obtained by cutting the prodomain of the latent form, resulting in a product of 82 kDa, which produces the active form of the enzyme. The third isoform is a heterodimer that originates from the binding of MMP-9 with the inhibitor TIMP-1, generating a product of 220 kDa. Finally, the fourth isoform corresponds to a 125 kDa heterodimer, made up of MMP-9 associated with lipocalin. Analysis of MMP-9 isoforms identification and determination of activities | Homo sapiens |
physiological function | variations in MMP-9 isoforms are observed, which coincide with the progression of tuberculosis infection. MMP-9 isoforms might influence the formation and progression of granuloma | Homo sapiens |