Application | Comment | Organism |
---|---|---|
medicine | breast cancer cell lines MCF-7, SKBR-3, and MDA-MB-231 expressing wild-type MMP-8 reveal elevated levels of interleukins IL-6 and IL-8. This increase is mirrored at the mRNA level and is dependent on MMP-8 catalytic activity. Sustained expression of wild-type MMP-8 by breast cancer cells is non-permissive for long-term growth.In long-term culture of transfected MDA-MB-231 cells, expression of wild-type but not E198A mutant MMP-8 is lost, with IL-6 and IL-8 levels returning to base line | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
E198A | catalytically inactive | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P22894 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MCF-7 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
SK-BR-3 cell | - |
Homo sapiens | - |