Cloned (Comment) | Organism |
---|---|
gene bmp1, recombinant expression in Escherichia coli strain BL21(DE3) | Bacillus thuringiensis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | 30-40% inhibition at 4-8 mM | Bacillus thuringiensis | |
Co2+ | 30% activation at 8 mM, 40% inhibition at 10 mM | Bacillus thuringiensis | |
EDTA | about 50% inhibition at 4-10 mM | Bacillus thuringiensis | |
Mg2+ | 72% inhibition at 4-8 mM | Bacillus thuringiensis | |
Mn2+ | 64% inhibition at 4-8 mM | Bacillus thuringiensis | |
pepstatin A | slight inhibition | Bacillus thuringiensis | |
PMSF | about 50% inhibition at 4-8 mM | Bacillus thuringiensis | |
Zn2+ | 57% inhibition at 8 mM | Bacillus thuringiensis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Co2+ | 30% activation at 8 mM, 40% inhibition at 10 mM | Bacillus thuringiensis | |
additional information | no effect by Ca2+ | Bacillus thuringiensis | |
Zn2+ | required, exogenous Zn2+ activates at 1 mM | Bacillus thuringiensis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Bacillus thuringiensis | purified Bmp1 protein shows metalloproteinase activity and toxicity against Caenorhabditis elegans, Bmp1 protein destroys the intestinal tissues of Caenorhabditis elegans | ? | - |
? | |
additional information | Bacillus thuringiensis YBT-1518 | purified Bmp1 protein shows metalloproteinase activity and toxicity against Caenorhabditis elegans, Bmp1 protein destroys the intestinal tissues of Caenorhabditis elegans | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacillus thuringiensis | L0AQH5 | gene bmp1 | - |
Bacillus thuringiensis YBT-1518 | L0AQH5 | gene bmp1 | - |
Purification (Comment) | Organism |
---|---|
recombinant enzyme from Escherichia coli strain BL21(DE3) | Bacillus thuringiensis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
casein + H2O | - |
Bacillus thuringiensis | ? | - |
? | |
casein + H2O | - |
Bacillus thuringiensis YBT-1518 | ? | - |
? | |
additional information | purified Bmp1 protein shows metalloproteinase activity and toxicity against Caenorhabditis elegans, Bmp1 protein destroys the intestinal tissues of Caenorhabditis elegans | Bacillus thuringiensis | ? | - |
? | |
additional information | purified Bmp1 protein shows metalloproteinase activity and toxicity against Caenorhabditis elegans, Bmp1 protein destroys the intestinal tissues of Caenorhabditis elegans | Bacillus thuringiensis YBT-1518 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BMP1 | - |
Bacillus thuringiensis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
40 | - |
- |
Bacillus thuringiensis |
Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
---|---|---|---|
20 | 60 | activity range, recombinant enzyme | Bacillus thuringiensis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
- |
Bacillus thuringiensis |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5 | 10 | activity range, recombinant enzyme | Bacillus thuringiensis |
General Information | Comment | Organism |
---|---|---|
evolution | metalloproteinase Bmp1 encompasses a consecutive N-terminal signal peptide, an FTP superfamily domain, an M4 neutral protease GluZincin superfamily, two Big-3 superfamily motifs, and a Gram-positive anchor superfamily motif as a C-terminal domain | Bacillus thuringiensis |
physiological function | Bmp1 metalloproteinase is a nematicidal virulence factor, purified Bmp1 protein shows metalloproteinase activity and toxicity against Caenorhabditis elegans, addition of Cry5Ba to Bmp1 protein enhances the toxicity by 7.9fold | Bacillus thuringiensis |