Literature summary for 3.4.24.24 extracted from

Nicolai, E.; Sinibaldi, F.; Sannino, G.; Lagana, G.; Basoli, F.; Licoccia, S.; Cozza, P.; Santucci, R.; Piro, M.C.
Omega-3 and omega-6 fatty acids act as inhibitors of the matrix metalloproteinase-2 and matrix metalloproteinase-9 activity (2017), Protein J., 36, 278-285 .

Search for more literature for 3.4.24.24

Inhibitors

Inhibitors	Comment	Organism	Structure
alpha-linolenic acid	-	Homo sapiens
docosahexaenoic acid	-	Homo sapiens
gamma-linolenic acid	-	Homo sapiens
linoleic acid	-	Homo sapiens
additional information	omega-3 and omega-6 fatty acids act as inhibitors of matrix metalloproteinase-2 activity. Omega-3 and omega-6 fatty acids contribute to the structure and function of the phospholipid bilayers in cellular membranes and act as precursors of lipid-mediated signaling molecules	Homo sapiens
oleic acid	-	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	the enzyme is secreted	Homo sapiens	-	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	required	Homo sapiens
Zn2+	a zinc-dependent metalloprotease	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P08253	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	activation of pro-MMP-2 with 1 mM APMA (p-aminophenylmercuric acetate) for 1 h at 37°C, in buffer containing 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM CaCl2, and 0.05% Brij L23	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
commercial preparation	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Mca-KPLGL-(Dpa)-AR-NH2 + H2O	-	Homo sapiens	?	-	?
additional information	enzyme activity is determined using human teeth as substrate	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
Matrix metalloproteinase 2	-	Homo sapiens
MMP-2	-	Homo sapiens
progelatinase	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
20	22	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	assay at	Homo sapiens

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Release 2023.1 (January 2023)