Cloned (Comment) | Organism |
---|---|
expression analysis | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
extracellular matrix | - |
Homo sapiens | 31012 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | matrilysins proteolyze a number of extracellular matrix/basement membrane components, including type IV collagens and proteoglycans | ? | - |
? | |
Type IV collagen + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | MMP-7 is activated from a pro-MMP-7 form | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelial lining fluid | i.e. ELF, proMMP-7 protein is not detectable in any of the 3 HIV1- groups, including HIV1- smokers with early emphysema. In contrast, ELF pro-MMP-7 is readily detectable in the ELF of HIV1+ smokers with early emphysema | Homo sapiens | - |
lung | HIV1- smokers with early emphysema have a trend toward increased relative alveolar matrilysin/MMP-7 gene expression compared with HIV1- healthy smokers and HIV1- healthy nonsmokers. HIV1+ smokers with early emphysema have significantly higher relative expression of alveolar mucosa MMP-7 than both HIV1- healthy smokers and HIV1- healthy nonsmokers. HIV1+ smokers with early emphysema have increased expression over and above the increase in HIV- smokers with early emphysema, overview | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | matrilysins proteolyze a number of extracellular matrix/basement membrane components, including type IV collagens and proteoglycans | Homo sapiens | ? | - |
? | |
Type IV collagen + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MMP-7 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | matrilysin is important for neutrophil migration into the lung in animal models of lung inflammation | Homo sapiens |