Application | Comment | Organism |
---|---|---|
medicine | enzyme is involved in cell dissociation and the subsequent invasion of pancreatic cancer cells. It induces the disruption of tight junction structure and forms a positive feedback loop with activation of the epidermal growth factor receptor mediated MEK-ERK signalling pathway | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pancreatic cancer cell | exclusive detection of active enzyme in conditioned medium of dissociated cells, detection of proenzyme only in conditioned medium of non-dissociated cells. Enzyme protein is greatly reduced by treatment with the epidermal growth factor receptor inhibitor AG1478 and the mitogen activated protein kinase kinase inhibitor U0126 | Homo sapiens | - |