Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Trypsin | activated by limited trypsin digestion | Mus musculus |
Cloned (Comment) | Organism |
---|---|
pcDNAI/Amp plasmid containing full-length wild-type meprin alpha-subunit cDNA transfected into MDCK cells and human embryonic kidney 293 cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
N152Q | site-directed mutagenesis | Mus musculus |
N234Q | site-directed mutagenesis | Mus musculus |
N270Q | site-directed mutagenesis | Mus musculus |
N330Q | site-directed mutagenesis | Mus musculus |
N41Q | site-directed mutagenesis | Mus musculus |
N426Q | site-directed mutagenesis | Mus musculus |
N452Q | site-directed mutagenesis | Mus musculus |
N546Q | site-directed mutagenesis | Mus musculus |
N553Q | site-directed mutagenesis | Mus musculus |
N614Q | site-directed mutagenesis | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | membrane-bound | Mus musculus | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | zinc metalloendopeptidase | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
95000 | - |
SDS-PAGE | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
mouse | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.9 | - |
mutant N152Q | Mus musculus |
1.4 | - |
mutant N426Q and N41Q | Mus musculus |
1.6 | - |
mutant N614Q | Mus musculus |
2 | - |
mutant N270Q | Mus musculus |
2.1 | - |
mutant N330Q | Mus musculus |
2.2 | - |
mutant N546Q | Mus musculus |
2.4 | - |
mutant N234Q | Mus musculus |
3.2 | - |
wild-type | Mus musculus |
3.3 | - |
mutant N553Q | Mus musculus |
5.9 | - |
mutant N452Q | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
meprin A metalloprotease | - |
Mus musculus |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
55 | - |
wild-type enzyme retains 55% activity after 20 min, similar results for the mutants N41Q, N330Q, N426Q, N452Q, N546Q, and N553Q, mutants N234Q, N270Q, and N614Q retains 10% activity after 20 min, N152Q retains 6% activity after 5 min | Mus musculus |