Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | the enzyme is secreted | Mus musculus | - |
- |
extracellular | the enzyme is secreted | Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
DBA/1J mice | - |
Mus musculus DBA/1J | - |
DBA/1J mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cartilage | - |
Homo sapiens | - |
chondrocyte | - |
Homo sapiens | - |
paw | collagen-induced arthritis hind paw sections as a model of human rheumatoid arthritis | Mus musculus | - |
SW-1353 cell | a human chondrosarcoma cell line | Homo sapiens | - |
synovial tissue | - |
Homo sapiens | - |
synoviocyte | fibroblast-like, from rheumatoid arthritis patients | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
matrix metalloproteinase-3 | - |
Mus musculus |
matrix metalloproteinase-3 | - |
Homo sapiens |
MMP-3 | - |
Mus musculus |
MMP-3 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | expression of MMP-3 in cartilages and synovial tissues is suppressed by the treatment of curcumin and indomethacin. Production of MMP-3 is inhibited by curcumin in tumor necrosis factor-alpha-stimulated rheumatoid arthritis fibroblast-like synoviocytes and chondrocytes in a dose-dependent manner putatively through the inhibition of PKCdelta and the JNK/c-Jun signaling pathway, overview | down |
Mus musculus | production of MMP-3 is inhibited by curcumin in collagen-induced arthritis hind paw sections in a dose-dependent manner putatively through the inhibition of PKCdelta and the JNK/c-Jun signaling pathway, overview | down |
Homo sapiens | TNF-alpha and IL-1beta stimulate production of MMPs through the activation of mitogen-activated protein kinases, NF-kappaB and AP-1 | up |